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Janus microparticles-based targeted and spatially-controlled piezoelectric neural stimulation via low-intensity focused ultrasound

Author

Listed:
  • Mertcan Han

    (Max Planck Institute for Intelligent Systems
    ETH Zurich)

  • Erdost Yildiz

    (Max Planck Institute for Intelligent Systems)

  • Ugur Bozuyuk

    (Max Planck Institute for Intelligent Systems)

  • Asli Aydin

    (Max Planck Institute for Intelligent Systems
    Maastricht University Medical Centre)

  • Yan Yu

    (Max Planck Institute for Intelligent Systems)

  • Aarushi Bhargava

    (Max Planck Institute for Intelligent Systems)

  • Selcan Karaz

    (Max Planck Institute for Intelligent Systems
    ETH Zurich)

  • Metin Sitti

    (Max Planck Institute for Intelligent Systems
    ETH Zurich
    Koç University)

Abstract

Electrical stimulation is a fundamental tool in studying neural circuits, treating neurological diseases, and advancing regenerative medicine. Injectable, free-standing piezoelectric particle systems have emerged as non-genetic and wireless alternatives for electrode-based tethered stimulation systems. However, achieving cell-specific and high-frequency piezoelectric neural stimulation remains challenging due to high-intensity thresholds, non-specific diffusion, and internalization of particles. Here, we develop cell-sized 20 μm-diameter silica-based piezoelectric magnetic Janus microparticles (PEMPs), enabling clinically-relevant high-frequency neural stimulation of primary neurons under low-intensity focused ultrasound. Owing to its functionally anisotropic design, half of the PEMP acts as a piezoelectric electrode via conjugated barium titanate nanoparticles to induce electrical stimulation, while the nickel-gold nanofilm-coated magnetic half provides spatial and orientational control on neural stimulation via external uniform rotating magnetic fields. Furthermore, surface functionalization with targeting antibodies enables cell-specific binding/targeting and stimulation of dopaminergic neurons. Taking advantage of such functionalities, the PEMP design offers unique features towards wireless neural stimulation for minimally invasive treatment of neurological diseases.

Suggested Citation

  • Mertcan Han & Erdost Yildiz & Ugur Bozuyuk & Asli Aydin & Yan Yu & Aarushi Bhargava & Selcan Karaz & Metin Sitti, 2024. "Janus microparticles-based targeted and spatially-controlled piezoelectric neural stimulation via low-intensity focused ultrasound," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-46245-4
    DOI: 10.1038/s41467-024-46245-4
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    References listed on IDEAS

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    4. Sarah-Anna Hescham & Po-Han Chiang & Danijela Gregurec & Junsang Moon & Michael G. Christiansen & Ali Jahanshahi & Huajie Liu & Dekel Rosenfeld & Arnd Pralle & Polina Anikeeva & Yasin Temel, 2021. "Magnetothermal nanoparticle technology alleviates parkinsonian-like symptoms in mice," Nature Communications, Nature, vol. 12(1), pages 1-10, December.
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