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Visualization-enhanced under-oil open microfluidic system for in situ characterization of multi-phase chemical reactions

Author

Listed:
  • Qiyuan Chen

    (University of Wisconsin-Madison)

  • Hang Zhai

    (University of Wisconsin-Madison)

  • David J. Beebe

    (University of Wisconsin-Madison
    Department of Pathology and Laboratory Medicine
    University of Wisconsin-Madison)

  • Chao Li

    (University of Wisconsin-Madison)

  • Bu Wang

    (University of Wisconsin-Madison
    University of Wisconsin-Madison)

Abstract

Under-oil open microfluidic system, utilizing liquid-liquid boundaries for confinements, offers inherent advantages including clogging-free flow channels, flexible access to samples, and adjustable gas permeation, making it well-suited for studying multi-phase chemical reactions that are challenging for closed microfluidics. However, reports on the novel system have primarily focused on device fabrication and functionality demonstrations within biology, leaving their application in broader chemical analysis underexplored. Here, we present a visualization-enhanced under-oil open microfluidic system for in situ characterization of multi-phase chemical reactions with Raman spectroscopy. The enhanced system utilizes a semi-transparent silicon (Si) nanolayer over the substrate to enhance visualization in both inverted and upright microscope setups while reducing Raman noise from the substrate. We validated the system’s chemical stability and capability to monitor gas evolution and gas-liquid reactions in situ. The enhanced under-oil open microfluidic system, integrating Raman spectroscopy, offers a robust open-microfluidic platform for label-free molecular sensing and real-time chemical/biochemical process monitoring in multi-phase systems.

Suggested Citation

  • Qiyuan Chen & Hang Zhai & David J. Beebe & Chao Li & Bu Wang, 2024. "Visualization-enhanced under-oil open microfluidic system for in situ characterization of multi-phase chemical reactions," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-45076-7
    DOI: 10.1038/s41467-024-45076-7
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    References listed on IDEAS

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    1. Wenqian Feng & Yu Chai & Joe Forth & Paul D. Ashby & Thomas P. Russell & Brett A. Helms, 2019. "Harnessing liquid-in-liquid printing and micropatterned substrates to fabricate 3-dimensional all-liquid fluidic devices," Nature Communications, Nature, vol. 10(1), pages 1-9, December.
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