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Dual electrical stimulation at spinal-muscular interface reconstructs spinal sensorimotor circuits after spinal cord injury

Author

Listed:
  • Kai Zhou

    (The Second Affiliated Hospital of Soochow University
    Nantong University)

  • Wei Wei

    (The Second Affiliated Hospital of Soochow University)

  • Dan Yang

    (The Second Affiliated Hospital of Soochow University
    Guizhou Medical University)

  • Hui Zhang

    (The Second Affiliated Hospital of Soochow University)

  • Wei Yang

    (The Second Affiliated Hospital of Soochow University)

  • Yunpeng Zhang

    (Chinese Academy of Sciences)

  • Yingnan Nie

    (Fudan University)

  • Mingming Hao

    (Chinese Academy of Sciences
    Ningbo Medical Centre Lihuili Hospital)

  • Pengcheng Wang

    (Soochow University)

  • Hang Ruan

    (Soochow University)

  • Ting Zhang

    (Chinese Academy of Sciences)

  • Shouyan Wang

    (Fudan University)

  • Yaobo Liu

    (The Second Affiliated Hospital of Soochow University
    Nantong University)

Abstract

The neural signals produced by varying electrical stimulation parameters lead to characteristic neural circuit responses. However, the characteristics of neural circuits reconstructed by electrical signals remain poorly understood, which greatly limits the application of such electrical neuromodulation techniques for the treatment of spinal cord injury. Here, we develop a dual electrical stimulation system that combines epidural electrical and muscle stimulation to mimic feedforward and feedback electrical signals in spinal sensorimotor circuits. We demonstrate that a stimulus frequency of 10−20 Hz under dual stimulation conditions is required for structural and functional reconstruction of spinal sensorimotor circuits, which not only activates genes associated with axonal regeneration of motoneurons, but also improves the excitability of spinal neurons. Overall, the results provide insights into neural signal decoding during spinal sensorimotor circuit reconstruction, suggesting that the combination of epidural electrical and muscle stimulation is a promising method for the treatment of spinal cord injury.

Suggested Citation

  • Kai Zhou & Wei Wei & Dan Yang & Hui Zhang & Wei Yang & Yunpeng Zhang & Yingnan Nie & Mingming Hao & Pengcheng Wang & Hang Ruan & Ting Zhang & Shouyan Wang & Yaobo Liu, 2024. "Dual electrical stimulation at spinal-muscular interface reconstructs spinal sensorimotor circuits after spinal cord injury," Nature Communications, Nature, vol. 15(1), pages 1-26, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-44898-9
    DOI: 10.1038/s41467-024-44898-9
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    References listed on IDEAS

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