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Neonatal brain dynamic functional connectivity in term and preterm infants and its association with early childhood neurodevelopment

Author

Listed:
  • Lucas G. S. França

    (King’s College London
    King’s College London
    Northumbria University)

  • Judit Ciarrusta

    (King’s College London
    King’s College London)

  • Oliver Gale-Grant

    (King’s College London
    King’s College London)

  • Sunniva Fenn-Moltu

    (King’s College London
    King’s College London)

  • Sean Fitzgibbon

    (University of Oxford)

  • Andrew Chew

    (King’s College London)

  • Shona Falconer

    (King’s College London)

  • Ralica Dimitrova

    (King’s College London
    King’s College London)

  • Lucilio Cordero-Grande

    (King’s College London
    Universidad Politécnica de Madrid
    Instituto de Salud Carlos III)

  • Anthony N. Price

    (King’s College London)

  • Emer Hughes

    (King’s College London)

  • Jonathan O’Muircheartaigh

    (King’s College London
    King’s College London
    King’s College London)

  • Eugene Duff

    (University of Oxford
    Imperial College London
    UK Dementia Research Institute at Imperial College London)

  • Jetro J. Tuulari

    (University of Turku
    University of Turku
    University of Turku and Turku University Hospital)

  • Gustavo Deco

    (Pompeu Fabra University
    Catalan Institution for Research and Advanced Studies
    Max Planck Institute for Human Cognitive and Brain Sciences
    Monash University)

  • Serena J. Counsell

    (King’s College London)

  • Joseph V. Hajnal

    (King’s College London)

  • Chiara Nosarti

    (King’s College London
    King’s College London)

  • Tomoki Arichi

    (King’s College London
    King’s College London
    Guy’s and St Thomas’ NHS Foundation Trust
    Imperial College London)

  • A. David Edwards

    (King’s College London
    King’s College London)

  • Grainne McAlonan

    (King’s College London)

  • Dafnis Batalle

    (King’s College London
    King’s College London)

Abstract

Brain dynamic functional connectivity characterises transient connections between brain regions. Features of brain dynamics have been linked to emotion and cognition in adult individuals, and atypical patterns have been associated with neurodevelopmental conditions such as autism. Although reliable functional brain networks have been consistently identified in neonates, little is known about the early development of dynamic functional connectivity. In this study we characterise dynamic functional connectivity with functional magnetic resonance imaging (fMRI) in the first few weeks of postnatal life in term-born (n = 324) and preterm-born (n = 66) individuals. We show that a dynamic landscape of brain connectivity is already established by the time of birth in the human brain, characterised by six transient states of neonatal functional connectivity with changing dynamics through the neonatal period. The pattern of dynamic connectivity is atypical in preterm-born infants, and associated with atypical social, sensory, and repetitive behaviours measured by the Quantitative Checklist for Autism in Toddlers (Q-CHAT) scores at 18 months of age.

Suggested Citation

  • Lucas G. S. França & Judit Ciarrusta & Oliver Gale-Grant & Sunniva Fenn-Moltu & Sean Fitzgibbon & Andrew Chew & Shona Falconer & Ralica Dimitrova & Lucilio Cordero-Grande & Anthony N. Price & Emer Hug, 2024. "Neonatal brain dynamic functional connectivity in term and preterm infants and its association with early childhood neurodevelopment," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-023-44050-z
    DOI: 10.1038/s41467-023-44050-z
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    References listed on IDEAS

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    1. Matthew F. Glasser & Timothy S. Coalson & Emma C. Robinson & Carl D. Hacker & John Harwell & Essa Yacoub & Kamil Ugurbil & Jesper Andersson & Christian F. Beckmann & Mark Jenkinson & Stephen M. Smith , 2016. "A multi-modal parcellation of human cerebral cortex," Nature, Nature, vol. 536(7615), pages 171-178, August.
    2. Takamitsu Watanabe & Geraint Rees, 2017. "Brain network dynamics in high-functioning individuals with autism," Nature Communications, Nature, vol. 8(1), pages 1-14, December.
    3. Anton Tokariev & James A. Roberts & Andrew Zalesky & Xuelong Zhao & Sampsa Vanhatalo & Michael Breakspear & Luca Cocchi, 2019. "Large-scale brain modes reorganize between infant sleep states and carry prognostic information for preterms," Nature Communications, Nature, vol. 10(1), pages 1-9, December.
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