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Associations of myeloid cells with cellular and humoral responses following vaccinations in patients with neuroimmunological diseases

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  • Meng Wang

    (a cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité—Universitätsmedizin Berlin
    Charité—Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin
    Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC))

  • Adeline Dehlinger

    (a cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité—Universitätsmedizin Berlin
    Charité—Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin
    Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC))

  • Camila Fernández Zapata

    (a cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité—Universitätsmedizin Berlin
    Charité—Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin
    Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC))

  • Maya Golan

    (Sourasky Medical Center, Tel Aviv Sourasky Medical Center)

  • Gerardina Gallaccio

    (a cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité—Universitätsmedizin Berlin
    Charité—Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin
    Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC))

  • Leif E. Sander

    (Charité—Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health)

  • Stephan Schlickeiser

    (Charité—Universitätsmedizin Berlin, and Berlin Institute of Health Berlin)

  • Desiree Kunkel

    (Berlin Institute of Health at Charité—Universitätsmedizin Berlin)

  • Tanja Schmitz-Hübsch

    (a cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité—Universitätsmedizin Berlin
    Charité—Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin
    Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC)
    Charité—Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health)

  • Birgit Sawitzki

    (Berlin Institute of Health at Charité—Universitätsmedizin Berlin)

  • Arnon Karni

    (Sourasky Medical Center, Tel Aviv Sourasky Medical Center
    Faculty of Medicine and Sagol School of Neuroscience Tel Aviv University)

  • Julian Braun

    (Si-M / “Der Simulierte Mensch” a science framework of Technische Universität Berlin and Charité—Universitätsmedizin Berlin
    Berlin Institute of Health (BIH) at Charité—Universitätsmedizin Berlin, Immunomics—Regenerative Immunology and Aging)

  • Lucie Loyal

    (Si-M / “Der Simulierte Mensch” a science framework of Technische Universität Berlin and Charité—Universitätsmedizin Berlin
    Berlin Institute of Health (BIH) at Charité—Universitätsmedizin Berlin, Immunomics—Regenerative Immunology and Aging)

  • Andreas Thiel

    (Si-M / “Der Simulierte Mensch” a science framework of Technische Universität Berlin and Charité—Universitätsmedizin Berlin
    Berlin Institute of Health (BIH) at Charité—Universitätsmedizin Berlin, Immunomics—Regenerative Immunology and Aging)

  • Judith Bellmann-Strobl

    (a cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité—Universitätsmedizin Berlin
    Charité—Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin
    Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC))

  • Friedemann Paul

    (a cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité—Universitätsmedizin Berlin
    Charité—Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin
    Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC)
    Charité—Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health)

  • Lil Meyer-Arndt

    (Charité—Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health
    Si-M / “Der Simulierte Mensch” a science framework of Technische Universität Berlin and Charité—Universitätsmedizin Berlin
    Charité—Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health)

  • Chotima Böttcher

    (a cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité—Universitätsmedizin Berlin
    Charité—Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin
    Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC))

Abstract

Disease-modifying therapies (DMTs) are widely used in neuroimmunological diseases such as multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD). Although these treatments are known to predispose patients to infections and affect their responses to vaccination, little is known about the impact of DMTs on the myeloid cell compartment. In this study, we use mass cytometry to examine DMT-associated changes in the innate immune system in untreated and treated patients with MS (n = 39) or NMOSD (n = 23). We also investigated the association between changes in myeloid cell phenotypes and longitudinal responsiveness to homologous primary, secondary, and tertiary SARS-CoV-2 mRNA vaccinations. Multiple DMT-associated myeloid cell clusters, in particular CD64+HLADRlow granulocytes, showed significant correlations with B and T cell responses induced by vaccination. Our findings suggest the potential role of myeloid cells in cellular and humoral responses following vaccination in DMT-treated patients with neuroimmunological diseases.

Suggested Citation

  • Meng Wang & Adeline Dehlinger & Camila Fernández Zapata & Maya Golan & Gerardina Gallaccio & Leif E. Sander & Stephan Schlickeiser & Desiree Kunkel & Tanja Schmitz-Hübsch & Birgit Sawitzki & Arnon Kar, 2023. "Associations of myeloid cells with cellular and humoral responses following vaccinations in patients with neuroimmunological diseases," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-43553-z
    DOI: 10.1038/s41467-023-43553-z
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    References listed on IDEAS

    as
    1. Dachuan Zhang & Grace Chen & Deepa Manwani & Arthur Mortha & Chunliang Xu & Jeremiah J. Faith & Robert D. Burk & Yuya Kunisaki & Jung-Eun Jang & Christoph Scheiermann & Miriam Merad & Paul S. Frenette, 2015. "Neutrophil ageing is regulated by the microbiome," Nature, Nature, vol. 525(7570), pages 528-532, September.
    2. Julian Braun & Lucie Loyal & Marco Frentsch & Daniel Wendisch & Philipp Georg & Florian Kurth & Stefan Hippenstiel & Manuela Dingeldey & Beate Kruse & Florent Fauchere & Emre Baysal & Maike Mangold & , 2020. "SARS-CoV-2-reactive T cells in healthy donors and patients with COVID-19," Nature, Nature, vol. 587(7833), pages 270-274, November.
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