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Intrinsic factors and CD1d1 but not CD1d2 expression levels control invariant natural killer T cell subset differentiation

Author

Listed:
  • Ludivine Amable

    (Université Paris Cité, Institut de Recherche Saint-Louis (IRSL), EMiLy)

  • Luis Antonio Ferreira Martins

    (Université Paris Cité, Institut de Recherche Saint-Louis (IRSL), EMiLy)

  • Remi Pierre

    (Université Paris Descartes)

  • Marcio Cruseiro

    (Université Paris Descartes)

  • Ghita Chabab

    (Tumor Escape Resistance and Immunity department, Cancer Research Center of Lyon INSERM U1052, CNRS UMR 5286, Centre Léon Bérard)

  • Arnauld Sergé

    (Laboratoire Adhésion Inflammation (LAI), CNRS, INSERM, Aix-Marseille Université)

  • Camille Kergaravat

    (Université Paris Cité, Institut de Recherche Saint-Louis (IRSL), EMiLy)

  • Marc Delord

    (King’s College London)

  • Christophe Viret

    (CIRI, Centre International de Recherche en Infectiologie, Université de Lyon, INSERM U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon)

  • Jean Jaubert

    (Mouse Genetics Unit, Institut Pasteur)

  • Chaohong Liu

    (Huazhong University of Science Technology)

  • Saoussen Karray

    (Université Paris Cité, INSERM U976, Institut de Recherche Saint-Louis (IRSL), Hôpital Saint-Louis)

  • Julien C. Marie

    (Tumor Escape Resistance and Immunity department, Cancer Research Center of Lyon INSERM U1052, CNRS UMR 5286, Centre Léon Bérard)

  • Magali Irla

    (Centre d’Immunologie de Marseille-Luminy (CIML), CNRS, INSERM, Aix-Marseille Université)

  • Hristo Georgiev

    (Hannover Medical School)

  • Emmanuel Clave

    (Université Paris Cité, Institut de Recherche Saint-Louis (IRSL), EMiLy)

  • Antoine Toubert

    (Université Paris Cité, Institut de Recherche Saint-Louis (IRSL), EMiLy)

  • Bruno Lucas

    (Institut Cochin, Centre National de la Recherche Scientifique UMR8104, INSERM U1016, Université Paris Descartes)

  • Jihene Klibi

    (Université Paris Cité, Institut de Recherche Saint-Louis (IRSL), EMiLy)

  • Kamel Benlagha

    (Université Paris Cité, Institut de Recherche Saint-Louis (IRSL), EMiLy)

Abstract

Invariant natural killer T (NKT) cell subsets are defined based on their cytokine-production profiles and transcription factors. Their distribution is different in C57BL/6 (B6) and BALB/c mice, with a bias for NKT1 and NKT2/NKT17 subsets, respectively. Here, we show that the non-classical class I-like major histocompatibility complex CD1 molecules CD1d2, expressed in BALB/c and not in B6 mice, could not account for this difference. We find however that NKT cell subset distribution is intrinsic to bone marrow derived NKT cells, regardless of syngeneic CD1d-ligand recognition, and that multiple intrinsic factors are likely involved. Finally, we find that CD1d expression levels in combination with T cell antigen receptor signal strength could also influence NKT cell distribution and function. Overall, this study indicates that CD1d-mediated TCR signals and other intrinsic signals integrate to influence strain-specific NKT cell differentiation programs and subset distributions.

Suggested Citation

  • Ludivine Amable & Luis Antonio Ferreira Martins & Remi Pierre & Marcio Cruseiro & Ghita Chabab & Arnauld Sergé & Camille Kergaravat & Marc Delord & Christophe Viret & Jean Jaubert & Chaohong Liu & Sao, 2023. "Intrinsic factors and CD1d1 but not CD1d2 expression levels control invariant natural killer T cell subset differentiation," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-43424-7
    DOI: 10.1038/s41467-023-43424-7
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    References listed on IDEAS

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    1. Kathryn D. Tuttle & S. Harsha Krovi & Jingjing Zhang & Romain Bedel & Laura Harmacek & Lisa K. Peterson & Leonard L. Dragone & Adam Lefferts & Catherine Halluszczak & Kent Riemondy & Jay R. Hesselbert, 2018. "TCR signal strength controls thymic differentiation of iNKT cell subsets," Nature Communications, Nature, vol. 9(1), pages 1-13, December.
    2. Meng Zhao & Mattias N. D. Svensson & Koen Venken & Ashu Chawla & Shu Liang & Isaac Engel & Piotr Mydel & Jeremy Day & Dirk Elewaut & Nunzio Bottini & Mitchell Kronenberg, 2018. "Altered thymic differentiation and modulation of arthritis by invariant NKT cells expressing mutant ZAP70," Nature Communications, Nature, vol. 9(1), pages 1-17, December.
    3. Hristo Georgiev & Inga Ravens & Charaf Benarafa & Reinhold Förster & Günter Bernhardt, 2016. "Distinct gene expression patterns correlate with developmental and functional traits of iNKT subsets," Nature Communications, Nature, vol. 7(1), pages 1-14, December.
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