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A hybrid register and questionnaire study of Covid-19 and post-acute sick leave in Denmark

Author

Listed:
  • Elisabeth O’Regan

    (Statens Serum Institut)

  • Ingrid Bech Svalgaard

    (Statens Serum Institut)

  • Anna Irene Vedel Sørensen

    (Statens Serum Institut)

  • Lampros Spiliopoulos

    (Statens Serum Institut)

  • Peter Bager

    (Statens Serum Institut)

  • Nete Munk Nielsen

    (Statens Serum Institut
    University of Southern Denmark)

  • Jørgen Vinsløv Hansen

    (Statens Serum Institut)

  • Anders Koch

    (Statens Serum Institut
    University of Copenhagen
    Rigshospitalet University Hospital)

  • Steen Ethelberg

    (Statens Serum Institut
    University of Copenhagen)

  • Anders Hviid

    (Statens Serum Institut
    University of Copenhagen)

Abstract

Post-acute sick leave is an underexplored indicator of the societal burden of SARS-CoV-2. Here, we report findings about self-reported sick leave and risk factors thereof from a hybrid survey and register study, which include 37,482 RT-PCR confirmed SARS-CoV-2 cases and 51,336 test-negative controls who were tested during the index- and alpha-dominant waves. We observe that an additional 33 individuals per 1000 took substantial sick leave following acute infection compared to persons with no known history of infection, where substantial sick leave is defined as >1 month of sick leave within the period 1–9 months after the RT-PCR test date. Being female, 50–65 years, or having certain pre-existing health conditions such as obesity, chronic lung diseases, and fibromyalgia each increase risk for taking substantial sick leave. Altogether, these results may help motivate improved diagnostic and treatment options for persons living with post-Covid conditions.

Suggested Citation

  • Elisabeth O’Regan & Ingrid Bech Svalgaard & Anna Irene Vedel Sørensen & Lampros Spiliopoulos & Peter Bager & Nete Munk Nielsen & Jørgen Vinsløv Hansen & Anders Koch & Steen Ethelberg & Anders Hviid, 2023. "A hybrid register and questionnaire study of Covid-19 and post-acute sick leave in Denmark," Nature Communications, Nature, vol. 14(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-42048-1
    DOI: 10.1038/s41467-023-42048-1
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    References listed on IDEAS

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    1. Trine Brøns Nielsen & Steffen Leth & Mathilde Pedersen & Helle Dahl Harbo & Claus Vinther Nielsen & Cecilia Hee Laursen & Berit Schiøttz-Christensen & Lisa Gregersen Oestergaard, 2022. "Mental Fatigue, Activities of Daily Living, Sick Leave and Functional Status among Patients with Long COVID: A Cross-Sectional Study," IJERPH, MDPI, vol. 19(22), pages 1-15, November.
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