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The intersection of undernutrition, microbiome, and child development in the first years of life

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  • Fanette Fontaine

    (Food and Agriculture Organization of the United Nations
    Université Paris- Cité)

  • Sondra Turjeman

    (Bar-Ilan University)

  • Karel Callens

    (Food and Agriculture Organization of the United Nations)

  • Omry Koren

    (Bar-Ilan University)

Abstract

Undernutrition affects about one out of five children worldwide. It is associated with impaired growth, neurodevelopment deficits, and increased infectious morbidity and mortality. Undernutrition, however, cannot be solely attributed to a lack of food or nutrient deficiency but rather results from a complex mix of biological and environmental factors. Recent research has shown that the gut microbiome is intimately involved in the metabolism of dietary components, in growth, in the training of the immune system, and in healthy development. In this review, we look at these features in the first three years of life, which is a critical window for both microbiome establishment and maturation and child development. We also discuss the potential of the microbiome in undernutrition interventions, which could increase efficacy and improve child health outcomes.

Suggested Citation

  • Fanette Fontaine & Sondra Turjeman & Karel Callens & Omry Koren, 2023. "The intersection of undernutrition, microbiome, and child development in the first years of life," Nature Communications, Nature, vol. 14(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-39285-9
    DOI: 10.1038/s41467-023-39285-9
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