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Task-specific modulation of corticospinal neuron activity during motor learning in mice

Author

Listed:
  • Najet Serradj

    (Burke Neurological Institute)

  • Francesca Marino

    (University of California)

  • Yunuen Moreno-López

    (Burke Neurological Institute)

  • Amanda Bernstein

    (Burke Neurological Institute)

  • Sydney Agger

    (HAVAS Production Studios)

  • Marwa Soliman

    (Burke Neurological Institute)

  • Andrew Sloan

    (Vulintus, Inc.)

  • Edmund Hollis

    (Burke Neurological Institute
    Feil Family Brain and Mind Research Institute, Weill Cornell Medicine)

Abstract

Motor skill learning relies on the plasticity of the primary motor cortex as task acquisition drives cortical motor network remodeling. Large-scale cortical remodeling of evoked motor outputs occurs during the learning of corticospinal-dependent prehension behavior, but not simple, non-dexterous tasks. Here we determine the response of corticospinal neurons to two distinct motor training paradigms and assess the role of corticospinal neurons in the execution of a task requiring precise modulation of forelimb movement and one that does not. In vivo calcium imaging in mice revealed temporal coding of corticospinal activity coincident with the development of precise prehension movements, but not more simplistic movement patterns. Transection of the corticospinal tract and optogenetic regulation of corticospinal activity show the necessity for patterned corticospinal network activity in the execution of precise movements but not simplistic ones. Our findings reveal a critical role for corticospinal network modulation in the learning and execution of precise motor movements.

Suggested Citation

  • Najet Serradj & Francesca Marino & Yunuen Moreno-López & Amanda Bernstein & Sydney Agger & Marwa Soliman & Andrew Sloan & Edmund Hollis, 2023. "Task-specific modulation of corticospinal neuron activity during motor learning in mice," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-38418-4
    DOI: 10.1038/s41467-023-38418-4
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    References listed on IDEAS

    as
    1. Maria Soledad Esposito & Paolo Capelli & Silvia Arber, 2014. "Brainstem nucleus MdV mediates skilled forelimb motor tasks," Nature, Nature, vol. 508(7496), pages 351-356, April.
    2. Andrew J. Peters & Simon X. Chen & Takaki Komiyama, 2014. "Emergence of reproducible spatiotemporal activity during motor learning," Nature, Nature, vol. 510(7504), pages 263-267, June.
    3. Min Fu & Xinzhu Yu & Ju Lu & Yi Zuo, 2012. "Repetitive motor learning induces coordinated formation of clustered dendritic spines in vivo," Nature, Nature, vol. 483(7387), pages 92-95, March.
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