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The evolution and international spread of extensively drug resistant Shigella sonnei

Author

Listed:
  • Lewis C. E. Mason

    (NIHR HPRU in Gastrointestinal Infections at University of Liverpool
    Veterinary and Ecological Sciences)

  • David R. Greig

    (UK Health Security Agency)

  • Lauren A. Cowley

    (University of Bath)

  • Sally R. Partridge

    (The Westmead Institute for Medical Research
    Western Sydney Local Health District
    University of Sydney
    University of Sydney)

  • Elena Martinez

    (University of Sydney
    New South Wales Health Pathology)

  • Grace A. Blackwell

    (University of Sydney
    New South Wales Health Pathology)

  • Charlotte E. Chong

    (Veterinary and Ecological Sciences)

  • P. Malaka Silva

    (Veterinary and Ecological Sciences)

  • Rebecca J. Bengtsson

    (Veterinary and Ecological Sciences)

  • Jenny L. Draper

    (University of Sydney
    New South Wales Health Pathology)

  • Andrew N. Ginn

    (University of Sydney
    University of Sydney
    New South Wales Health Pathology
    Douglass Hanly Moir Pathology)

  • Indy Sandaradura

    (Western Sydney Local Health District
    University of Sydney
    New South Wales Health Pathology)

  • Eby M. Sim

    (The Westmead Institute for Medical Research
    Western Sydney Local Health District
    University of Sydney)

  • Jonathan R. Iredell

    (The Westmead Institute for Medical Research
    Western Sydney Local Health District
    University of Sydney
    University of Sydney)

  • Vitali Sintchenko

    (The Westmead Institute for Medical Research
    Western Sydney Local Health District
    University of Sydney
    University of Sydney)

  • Danielle J. Ingle

    (The University of Melbourne at The Peter Doherty Institute for Infection and Immunity)

  • Benjamin P. Howden

    (The University of Melbourne at The Peter Doherty Institute for Infection and Immunity)

  • Sophie Lefèvre

    (Université Paris Cité, Unité des Bactéries pathogènes entériques, Centre National de Référence des Escherichia coli, Shigella et Salmonella)

  • Elisabeth Njamkepo

    (Université Paris Cité, Unité des Bactéries pathogènes entériques, Centre National de Référence des Escherichia coli, Shigella et Salmonella)

  • François-Xavier Weill

    (Université Paris Cité, Unité des Bactéries pathogènes entériques, Centre National de Référence des Escherichia coli, Shigella et Salmonella)

  • Pieter-Jan Ceyssens

    (Division of Human Bacterial Diseases, Sciensano)

  • Claire Jenkins

    (UK Health Security Agency)

  • Kate S. Baker

    (NIHR HPRU in Gastrointestinal Infections at University of Liverpool
    Veterinary and Ecological Sciences)

Abstract

Shigella sonnei causes shigellosis, a severe gastrointestinal illness that is sexually transmissible among men who have sex with men (MSM). Multidrug resistance in S. sonnei is common including against World Health Organisation recommended treatment options, azithromycin, and ciprofloxacin. Recently, an MSM-associated outbreak of extended-spectrum β-lactamase producing, extensively drug resistant S. sonnei was reported in the United Kingdom. Here, we aimed to identify the genetic basis, evolutionary history, and international dissemination of the outbreak strain. Our genomic epidemiological analyses of 3,304 isolates from the United Kingdom, Australia, Belgium, France, and the United States of America revealed an internationally connected outbreak with a most recent common ancestor in 2018 carrying a low-fitness cost resistance plasmid, previously observed in travel associated sublineages of S. flexneri. Our results highlight the persistent threat of horizontally transmitted antimicrobial resistance and the value of continuing to work towards early and open international sharing of genomic surveillance data.

Suggested Citation

  • Lewis C. E. Mason & David R. Greig & Lauren A. Cowley & Sally R. Partridge & Elena Martinez & Grace A. Blackwell & Charlotte E. Chong & P. Malaka Silva & Rebecca J. Bengtsson & Jenny L. Draper & Andre, 2023. "The evolution and international spread of extensively drug resistant Shigella sonnei," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-37672-w
    DOI: 10.1038/s41467-023-37672-w
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    References listed on IDEAS

    as
    1. Jane Hawkey & Kalani Paranagama & Kate S. Baker & Rebecca J. Bengtsson & François-Xavier Weill & Nicholas R. Thomson & Stephen Baker & Louise Cerdeira & Zamin Iqbal & Martin Hunt & Danielle J. Ingle &, 2021. "Global population structure and genotyping framework for genomic surveillance of the major dysentery pathogen, Shigella sonnei," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    2. Kate S. Baker & Timothy J. Dallman & Nigel Field & Tristan Childs & Holly Mitchell & Martin Day & François-Xavier Weill & Sophie Lefèvre & Mathieu Tourdjman & Gwenda Hughes & Claire Jenkins & Nicholas, 2018. "Horizontal antimicrobial resistance transfer drives epidemics of multiple Shigella species," Nature Communications, Nature, vol. 9(1), pages 1-10, December.
    3. Phelim Bradley & N. Claire Gordon & Timothy M. Walker & Laura Dunn & Simon Heys & Bill Huang & Sarah Earle & Louise J. Pankhurst & Luke Anson & Mariateresa de Cesare & Paolo Piazza & Antonina A. Votin, 2015. "Rapid antibiotic-resistance predictions from genome sequence data for Staphylococcus aureus and Mycobacterium tuberculosis," Nature Communications, Nature, vol. 6(1), pages 1-15, December.
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