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Volumetric additive manufacturing of pristine silk-based (bio)inks

Author

Listed:
  • Maobin Xie

    (Brigham and Women’s Hospital, Harvard Medical School
    The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People’s Hospital; School of Biomedical Engineering, Guangzhou Medical University)

  • Liming Lian

    (Brigham and Women’s Hospital, Harvard Medical School)

  • Xuan Mu

    (Brigham and Women’s Hospital, Harvard Medical School
    Tufts University)

  • Zeyu Luo

    (Brigham and Women’s Hospital, Harvard Medical School)

  • Carlos Ezio Garciamendez-Mijares

    (Brigham and Women’s Hospital, Harvard Medical School)

  • Zhenrui Zhang

    (Brigham and Women’s Hospital, Harvard Medical School)

  • Arturo López

    (Brigham and Women’s Hospital, Harvard Medical School)

  • Jennifer Manríquez

    (Brigham and Women’s Hospital, Harvard Medical School)

  • Xiao Kuang

    (Brigham and Women’s Hospital, Harvard Medical School)

  • Junqi Wu

    (Tufts University)

  • Jugal Kishore Sahoo

    (Tufts University)

  • Federico Zertuche González

    (Brigham and Women’s Hospital, Harvard Medical School)

  • Gang Li

    (Tufts University)

  • Guosheng Tang

    (Brigham and Women’s Hospital, Harvard Medical School)

  • Sushila Maharjan

    (Brigham and Women’s Hospital, Harvard Medical School)

  • Jie Guo

    (Brigham and Women’s Hospital, Harvard Medical School)

  • David L. Kaplan

    (Tufts University)

  • Yu Shrike Zhang

    (Brigham and Women’s Hospital, Harvard Medical School)

Abstract

Volumetric additive manufacturing (VAM) enables fast photopolymerization of three-dimensional constructs by illuminating dynamically evolving light patterns in the entire build volume. However, the lack of bioinks suitable for VAM is a critical limitation. This study reports rapid volumetric (bio)printing of pristine, unmodified silk-based (silk sericin (SS) and silk fibroin (SF)) (bio)inks to form sophisticated shapes and architectures. Of interest, combined with post-fabrication processing, the (bio)printed SS constructs reveal properties including reversible as well as repeated shrinkage and expansion, or shape-memory; whereas the (bio)printed SF constructs exhibit tunable mechanical performances ranging from a few hundred Pa to hundreds of MPa. Both types of silk-based (bio)inks are cytocompatible. This work supplies expanded bioink libraries for VAM and provides a path forward for rapid volumetric manufacturing of silk constructs, towards broadened biomedical applications.

Suggested Citation

  • Maobin Xie & Liming Lian & Xuan Mu & Zeyu Luo & Carlos Ezio Garciamendez-Mijares & Zhenrui Zhang & Arturo López & Jennifer Manríquez & Xiao Kuang & Junqi Wu & Jugal Kishore Sahoo & Federico Zertuche G, 2023. "Volumetric additive manufacturing of pristine silk-based (bio)inks," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-35807-7
    DOI: 10.1038/s41467-023-35807-7
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    References listed on IDEAS

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