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Hippocampus as a sorter and reverberatory integrator of sensory inputs

Author

Listed:
  • Masanori Nomoto

    (University of Toyama
    University of Toyama
    University of Toyama)

  • Emi Murayama

    (University of Toyama
    University of Toyama
    University of Toyama)

  • Shuntaro Ohno

    (University of Toyama
    University of Toyama
    University of Toyama)

  • Reiko Okubo-Suzuki

    (University of Toyama
    University of Toyama
    University of Toyama)

  • Shin-ichi Muramatsu

    (Jichi Medical University
    The University of Tokyo)

  • Kaoru Inokuchi

    (University of Toyama
    University of Toyama
    University of Toyama)

Abstract

The hippocampus must be capable of sorting and integrating multiple sensory inputs separately but simultaneously. However, it remains to be elucidated how the hippocampus executes these processes simultaneously during learning. Here we found that synchrony between conditioned stimulus (CS)-, unconditioned stimulus (US)- and future retrieval-responsible cells occurs in the CA1 during the reverberatory phase that emerges after sensory inputs have ceased, but not during CS and US inputs. Mutant mice lacking N-methyl-D-aspartate receptors (NRs) in CA3 showed a cued-fear memory impairment and a decrease in synchronized reverberatory activities between CS- and US-responsive CA1 cells. Optogenetic CA3 silencing at the reverberatory phase during learning impaired cued-fear memory. Thus, the hippocampus uses reverberatory activity to link CS and US inputs, and avoid crosstalk during sensory inputs.

Suggested Citation

  • Masanori Nomoto & Emi Murayama & Shuntaro Ohno & Reiko Okubo-Suzuki & Shin-ichi Muramatsu & Kaoru Inokuchi, 2022. "Hippocampus as a sorter and reverberatory integrator of sensory inputs," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-35119-2
    DOI: 10.1038/s41467-022-35119-2
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    References listed on IDEAS

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    1. Benjamin F. Grewe & Jan Gründemann & Lacey J. Kitch & Jerome A. Lecoq & Jones G. Parker & Jesse D. Marshall & Margaret C. Larkin & Pablo E. Jercog & Francois Grenier & Jin Zhong Li & Andreas Lüthi & M, 2017. "Neural ensemble dynamics underlying a long-term associative memory," Nature, Nature, vol. 543(7647), pages 670-675, March.
    2. Khaled Ghandour & Noriaki Ohkawa & Chi Chung Alan Fung & Hirotaka Asai & Yoshito Saitoh & Takashi Takekawa & Reiko Okubo-Suzuki & Shingo Soya & Hirofumi Nishizono & Mina Matsuo & Makoto Osanai & Masaa, 2019. "Orchestrated ensemble activities constitute a hippocampal memory engram," Nature Communications, Nature, vol. 10(1), pages 1-14, December.
    3. Masanori Nomoto & Noriaki Ohkawa & Hirofumi Nishizono & Jun Yokose & Akinobu Suzuki & Mina Matsuo & Shuhei Tsujimura & Yukari Takahashi & Masashi Nagase & Ayako M. Watabe & Fusao Kato & Kaoru Inokuchi, 2016. "Cellular tagging as a neural network mechanism for behavioural tagging," Nature Communications, Nature, vol. 7(1), pages 1-11, November.
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