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Reactive metal boride nanoparticles trap lipopolysaccharide and peptidoglycan for bacteria-infected wound healing

Author

Listed:
  • Yun Meng

    (Tongji University Cancer Center, Shanghai Tenth People’s Hospital, Tongji University School of Medicine
    Fudan University)

  • Lijie Chen

    (Fudan University)

  • Yang Chen

    (Tongji University Cancer Center, Shanghai Tenth People’s Hospital, Tongji University School of Medicine
    Tongji University)

  • Jieyun Shi

    (Tongji University Cancer Center, Shanghai Tenth People’s Hospital, Tongji University School of Medicine)

  • Zheng Zhang

    (East China Normal University)

  • Yiwen Wang

    (East China Normal University)

  • Fan Wu

    (Fudan University)

  • Xingwu Jiang

    (Fudan University)

  • Wei Yang

    (Tongji University Cancer Center, Shanghai Tenth People’s Hospital, Tongji University School of Medicine)

  • Li Zhang

    (Tongji University Cancer Center, Shanghai Tenth People’s Hospital, Tongji University School of Medicine)

  • Chaochao Wang

    (Tongji University Cancer Center, Shanghai Tenth People’s Hospital, Tongji University School of Medicine)

  • Xianfu Meng

    (Tongji University Cancer Center, Shanghai Tenth People’s Hospital, Tongji University School of Medicine)

  • Yelin Wu

    (Tongji University Cancer Center, Shanghai Tenth People’s Hospital, Tongji University School of Medicine)

  • Wenbo Bu

    (Tongji University Cancer Center, Shanghai Tenth People’s Hospital, Tongji University School of Medicine
    Fudan University)

Abstract

Bacteria and excessive inflammation are two main factors causing non-healing wounds. However, current studies have mainly focused on the inhibition of bacteria survival for wound healing while ignoring the excessive inflammation induced by dead bacteria-released lipopolysaccharide (LPS) or peptidoglycan (PGN). Herein, a boron-trapping strategy has been proposed to prevent both infection and excessive inflammation by synthesizing a class of reactive metal boride nanoparticles (MB NPs). Our results show that the MB NPs are gradually hydrolyzed to generate boron dihydroxy groups and metal cations while generating a local alkaline microenvironment. This microenvironment greatly enhances boron dihydroxy groups to trap LPS or PGN through an esterification reaction, which not only enhances metal cation-induced bacterial death but also inhibits dead bacteria-induced excessive inflammation both in vitro and in vivo, finally accelerating wound healing. Taken together, this boron-trapping strategy provides an approach to the treatment of bacterial infection and the accompanying inflammation.

Suggested Citation

  • Yun Meng & Lijie Chen & Yang Chen & Jieyun Shi & Zheng Zhang & Yiwen Wang & Fan Wu & Xingwu Jiang & Wei Yang & Li Zhang & Chaochao Wang & Xianfu Meng & Yelin Wu & Wenbo Bu, 2022. "Reactive metal boride nanoparticles trap lipopolysaccharide and peptidoglycan for bacteria-infected wound healing," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-35050-6
    DOI: 10.1038/s41467-022-35050-6
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    References listed on IDEAS

    as
    1. Haohao Dong & Quanju Xiang & Yinghong Gu & Zhongshan Wang & Neil G. Paterson & Phillip J. Stansfeld & Chuan He & Yizheng Zhang & Wenjian Wang & Changjiang Dong, 2014. "Structural basis for outer membrane lipopolysaccharide insertion," Nature, Nature, vol. 511(7507), pages 52-56, July.
    2. Xianli Su & Fan Fu & Yonggao Yan & Gang Zheng & Tao Liang & Qiang Zhang & Xin Cheng & Dongwang Yang & Hang Chi & Xinfeng Tang & Qingjie Zhang & Ctirad Uher, 2014. "Self-propagating high-temperature synthesis for compound thermoelectrics and new criterion for combustion processing," Nature Communications, Nature, vol. 5(1), pages 1-7, December.
    3. Z. L. Shaw & Sruthi Kuriakose & Samuel Cheeseman & Michael D. Dickey & Jan Genzer & Andrew J. Christofferson & Russell J. Crawford & Chris F. McConville & James Chapman & Vi Khanh Truong & Aaron Elbou, 2021. "Antipathogenic properties and applications of low-dimensional materials," Nature Communications, Nature, vol. 12(1), pages 1-19, December.
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