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Dynamics of extended-spectrum cephalosporin resistance genes in Escherichia coli from Europe and North America

Author

Listed:
  • Roxana Zamudio

    (Norwich Research Park)

  • Patrick Boerlin

    (University of Guelph)

  • Racha Beyrouthy

    (Université Clermont Auvergne
    Centre Hospitalier Universitaire de Clermont-Ferrand)

  • Jean-Yves Madec

    (Anses Laboratoire de Lyon, Université de Lyon)

  • Stefan Schwarz

    (Freie Universität Berlin
    Freie Universität Berlin)

  • Michael R. Mulvey

    (Public Health Agency of Canada)

  • George G. Zhanel

    (University of Manitoba)

  • Ashley Cormier

    (University of Guelph)

  • Gabhan Chalmers

    (University of Guelph)

  • Richard Bonnet

    (Université Clermont Auvergne
    Centre Hospitalier Universitaire de Clermont-Ferrand)

  • Marisa Haenni

    (Anses Laboratoire de Lyon, Université de Lyon)

  • Inga Eichhorn

    (Freie Universität Berlin
    Freie Universität Berlin)

  • Heike Kaspar

    (Resistance to Antibiotics Unit Monitoring of Resistance to Antibiotics, Federal Office of Consumer Protection and Food Safety)

  • Raquel Garcia-Fierro

    (Anses Laboratoire de Lyon, Université de Lyon)

  • James L. N. Wood

    (University of Cambridge)

  • Alison E. Mather

    (Norwich Research Park
    University of East Anglia)

Abstract

Extended-spectrum cephalosporins (ESCs) are critically important antimicrobial agents for human and veterinary medicine. ESC resistance (ESC-R) genes have spread worldwide through plasmids and clonal expansion, yet the distribution and dynamics of ESC-R genes in different ecological compartments are poorly understood. Here we use whole genome sequence data of Enterobacterales isolates of human and animal origin from Europe and North America and identify contrasting temporal dynamics. AmpC β-lactamases were initially more dominant in North America in humans and farm animals, only later emerging in Europe. In contrast, specific extended-spectrum β-lactamases (ESBLs) were initially common in animals from Europe and later emerged in North America. This study identifies differences in the relative importance of plasmids and clonal expansion across different compartments for the spread of different ESC-R genes. Understanding the mechanisms of transmission will be critical in the design of interventions to reduce the spread of antimicrobial resistance.

Suggested Citation

  • Roxana Zamudio & Patrick Boerlin & Racha Beyrouthy & Jean-Yves Madec & Stefan Schwarz & Michael R. Mulvey & George G. Zhanel & Ashley Cormier & Gabhan Chalmers & Richard Bonnet & Marisa Haenni & Inga , 2022. "Dynamics of extended-spectrum cephalosporin resistance genes in Escherichia coli from Europe and North America," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-34970-7
    DOI: 10.1038/s41467-022-34970-7
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    References listed on IDEAS

    as
    1. Chirag Jain & Luis M. Rodriguez-R & Adam M. Phillippy & Konstantinos T. Konstantinidis & Srinivas Aluru, 2018. "High throughput ANI analysis of 90K prokaryotic genomes reveals clear species boundaries," Nature Communications, Nature, vol. 9(1), pages 1-8, December.
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