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Supramolecular photodynamic agents for simultaneous oxidation of NADH and generation of superoxide radical

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  • Kun-Xu Teng

    (Beijing Normal University)

  • Li-Ya Niu

    (Beijing Normal University)

  • Nan Xie

    (Capital Medical University)

  • Qing-Zheng Yang

    (Beijing Normal University)

Abstract

Given that Type-I photosensitizers (PSs) have hypoxia tolerance, developing general approaches to prepare Type-I PSs is of great importance, but remains a challenge. Here, we report a supramolecular strategy for the preparation of Type-I photodynamic agents, which simultaneously generate strong oxidizing cationic radicals and superoxide radicals, by introducing electron acceptors to the existing Type-II PSs. As a proof-of-concept, three electron acceptors were designed and co-assembled with a classical PS to produce quadruple hydrogen-bonded supramolecular photodynamic agents. The photo-induced electron transfer from the PS to the adjacent electron acceptor occurs efficiently, leading to the generation of a strong oxidizing PS+• and an anionic radical of the acceptor, which further transfers an electron to oxygen to form O2−•. In addition, these photodynamic agents induce direct photocatalytic oxidation of NADH with a turnover frequency as high as 53.7 min−1, which offers an oxygen-independent mechanism to damage tumors.

Suggested Citation

  • Kun-Xu Teng & Li-Ya Niu & Nan Xie & Qing-Zheng Yang, 2022. "Supramolecular photodynamic agents for simultaneous oxidation of NADH and generation of superoxide radical," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-33924-3
    DOI: 10.1038/s41467-022-33924-3
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    References listed on IDEAS

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    1. Rozbeh Baradaran & John M. Berrisford & Gurdeep S. Minhas & Leonid A. Sazanov, 2013. "Crystal structure of the entire respiratory complex I," Nature, Nature, vol. 494(7438), pages 443-448, February.
    2. Jing An & Shanliang Tang & Gaobo Hong & Wenlong Chen & Miaomiao Chen & Jitao Song & Zhiliang Li & Xiaojun Peng & Fengling Song & Wen-Heng Zheng, 2022. "An unexpected strategy to alleviate hypoxia limitation of photodynamic therapy by biotinylation of photosensitizers," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    3. Zhengze Yu & Ping Zhou & Wei Pan & Na Li & Bo Tang, 2018. "A biomimetic nanoreactor for synergistic chemiexcited photodynamic therapy and starvation therapy against tumor metastasis," Nature Communications, Nature, vol. 9(1), pages 1-9, December.
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    Cited by:

    1. Yufu Tang & Yuanyuan Li & Bowen Li & Wentao Song & Guobin Qi & Jianwu Tian & Wei Huang & Quli Fan & Bin Liu, 2024. "Oxygen-independent organic photosensitizer with ultralow-power NIR photoexcitation for tumor-specific photodynamic therapy," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    2. Zhao Zhang & Zixiang Wei & Jintong Guo & Jinxiao Lyu & Bingzhe Wang & Gang Wang & Chunfei Wang & Liqiang Zhou & Zhen Yuan & Guichuan Xing & Changfeng Wu & Xuanjun Zhang, 2024. "Metallopolymer strategy to explore hypoxic active narrow-bandgap photosensitizers for effective cancer photodynamic therapy," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

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