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Nebulized fusion inhibitory peptide protects cynomolgus macaques from measles virus infection

Author

Listed:
  • Olivier Reynard

    (INSERM U1111, CNRS, UMR5308, Univ Lyon, Université Claude Bernard Lyon 1, École Normale Supérieure de Lyon)

  • Claudia Gonzalez

    (INSERM U1111, CNRS, UMR5308, Univ Lyon, Université Claude Bernard Lyon 1, École Normale Supérieure de Lyon)

  • Claire Dumont

    (INSERM U1111, CNRS, UMR5308, Univ Lyon, Université Claude Bernard Lyon 1, École Normale Supérieure de Lyon)

  • Mathieu Iampietro

    (INSERM U1111, CNRS, UMR5308, Univ Lyon, Université Claude Bernard Lyon 1, École Normale Supérieure de Lyon)

  • Marion Ferren

    (INSERM U1111, CNRS, UMR5308, Univ Lyon, Université Claude Bernard Lyon 1, École Normale Supérieure de Lyon)

  • Sandrine Guellec

    (Université de Tours)

  • Lajoie Laurie

    (Université de Tours, Institut national de recherche pour l’agriculture, l’alimentation et l’environnement (INRAe), UMR1282, Infectiologie et santé publique (ISP))

  • Cyrille Mathieu

    (INSERM U1111, CNRS, UMR5308, Univ Lyon, Université Claude Bernard Lyon 1, École Normale Supérieure de Lyon)

  • Gabrielle Carpentier

    (PST-A, Université de Tours)

  • Georges Roseau

    (PST-A, Université de Tours)

  • Francesca T. Bovier

    (Columbia University Vagelos College of Physicians and Surgeons)

  • Yun Zhu

    (Columbia University Vagelos College of Physicians and Surgeons
    Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health)

  • Deborah Pennec

    (CEPR U1100, Université de Tours)

  • Jérome Montharu

    (PST-A, Université de Tours)

  • Amin Addetia

    (University of Washington Medical Center)

  • Alexander L. Greninger

    (University of Washington Medical Center)

  • Christopher A. Alabi

    (Cornell University)

  • Elise Brisebard

    (UMR703, PAnTher APEX, INRAE/Oniris)

  • Anne Moscona

    (Columbia University Vagelos College of Physicians and Surgeons
    Columbia University Vagelos College of Physicians & Surgeons
    Columbia University Vagelos College of Physicians & Surgeons)

  • Laurent Vecellio

    (PST-A, Université de Tours)

  • Matteo Porotto

    (Columbia University Vagelos College of Physicians and Surgeons
    University of Studies of Campania ‘Luigi Vanvitelli’)

  • Branka Horvat

    (INSERM U1111, CNRS, UMR5308, Univ Lyon, Université Claude Bernard Lyon 1, École Normale Supérieure de Lyon)

Abstract

Measles is the most contagious airborne viral infection and the leading cause of child death among vaccine-preventable diseases. We show here that aerosolized lipopeptide fusion inhibitor, derived from heptad-repeat regions of the measles virus (MeV) fusion protein, blocks respiratory MeV infection in a non-human primate model, the cynomolgus macaque. We use a custom-designed mesh nebulizer to ensure efficient aerosol delivery of peptide to the respiratory tract and demonstrate the absence of adverse effects and lung pathology in macaques. The nebulized peptide efficiently prevents MeV infection, resulting in the complete absence of MeV RNA, MeV-infected cells, and MeV-specific humoral responses in treated animals. This strategy provides an additional means to fight against respiratory infection in non-vaccinated people, that can be readily translated to human trials. It presents a proof-of-concept for the aerosol delivery of fusion inhibitory peptides to protect against measles and other airborne viruses, including SARS-CoV-2, in case of high-risk exposure.

Suggested Citation

  • Olivier Reynard & Claudia Gonzalez & Claire Dumont & Mathieu Iampietro & Marion Ferren & Sandrine Guellec & Lajoie Laurie & Cyrille Mathieu & Gabrielle Carpentier & Georges Roseau & Francesca T. Bovie, 2022. "Nebulized fusion inhibitory peptide protects cynomolgus macaques from measles virus infection," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-33832-6
    DOI: 10.1038/s41467-022-33832-6
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    References listed on IDEAS

    as
    1. Leslie Roberts, 2020. "Why measles deaths are surging — and coronavirus could make it worse," Nature, Nature, vol. 580(7804), pages 446-447, April.
    2. Hironobu Tatsuo & Nobuyuki Ono & Kotaro Tanaka & Yusuke Yanagi, 2000. "SLAM (CDw150) is a cellular receptor for measles virus," Nature, Nature, vol. 406(6798), pages 893-897, August.
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