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WAVY GROWTH Arabidopsis E3 ubiquitin ligases affect apical PIN sorting decisions

Author

Listed:
  • Nataliia Konstantinova

    (University of Natural Resources and Life Sciences
    Ghent University)

  • Lukas Hoermayer

    (Institute of Science and Technology Austria (IST Austria))

  • Matouš Glanc

    (Ghent University
    Institute of Science and Technology Austria (IST Austria))

  • Rabab Keshkeih

    (University of Natural Resources and Life Sciences)

  • Shutang Tan

    (Institute of Science and Technology Austria (IST Austria)
    University of Science and Technology of China)

  • Martin Donato

    (University of Fribourg)

  • Katarzyna Retzer

    (University of Natural Resources and Life Sciences
    Institute of Experimental Botany of the Czech Academy of Sciences)

  • Jeanette Moulinier-Anzola

    (University of Natural Resources and Life Sciences)

  • Max Schwihla

    (University of Natural Resources and Life Sciences)

  • Barbara Korbei

    (University of Natural Resources and Life Sciences)

  • Markus Geisler

    (University of Fribourg)

  • Jiří Friml

    (Institute of Science and Technology Austria (IST Austria))

  • Christian Luschnig

    (University of Natural Resources and Life Sciences)

Abstract

Directionality in the intercellular transport of the plant hormone auxin is determined by polar plasma membrane localization of PIN-FORMED (PIN) auxin transport proteins. However, apart from PIN phosphorylation at conserved motifs, no further determinants explicitly controlling polar PIN sorting decisions have been identified. Here we present Arabidopsis WAVY GROWTH 3 (WAV3) and closely related RING-finger E3 ubiquitin ligases, whose loss-of-function mutants show a striking apical-to-basal polarity switch in PIN2 localization in root meristem cells. WAV3 E3 ligases function as essential determinants for PIN polarity, acting independently from PINOID/WAG-dependent PIN phosphorylation. They antagonize ectopic deposition of de novo synthesized PIN proteins already immediately following completion of cell division, presumably via preventing PIN sorting into basal, ARF GEF-mediated trafficking. Our findings reveal an involvement of E3 ligases in the selective targeting of apically localized PINs in higher plants.

Suggested Citation

  • Nataliia Konstantinova & Lukas Hoermayer & Matouš Glanc & Rabab Keshkeih & Shutang Tan & Martin Donato & Katarzyna Retzer & Jeanette Moulinier-Anzola & Max Schwihla & Barbara Korbei & Markus Geisler &, 2022. "WAVY GROWTH Arabidopsis E3 ubiquitin ligases affect apical PIN sorting decisions," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-32888-8
    DOI: 10.1038/s41467-022-32888-8
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    References listed on IDEAS

    as
    1. Yuzhou Zhang & Guanghui Xiao & Xiaojuan Wang & Xixi Zhang & Jiří Friml, 2019. "Evolution of fast root gravitropism in seed plants," Nature Communications, Nature, vol. 10(1), pages 1-10, December.
    2. Katarzyna Retzer & Maria Akhmanova & Nataliia Konstantinova & Kateřina Malínská & Johannes Leitner & Jan Petrášek & Christian Luschnig, 2019. "Brassinosteroid signaling delimits root gravitropism via sorting of the Arabidopsis PIN2 auxin transporter," Nature Communications, Nature, vol. 10(1), pages 1-15, December.
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    Cited by:

    1. Karin Vogel & Tobias Bläske & Marie-Kristin Nagel & Christoph Globisch & Shane Maguire & Lorenz Mattes & Christian Gude & Michael Kovermann & Karin Hauser & Christine Peter & Erika Isono, 2022. "Lipid-mediated activation of plasma membrane-localized deubiquitylating enzymes modulate endosomal trafficking," Nature Communications, Nature, vol. 13(1), pages 1-19, December.

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