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A mid-infrared lab-on-a-chip for dynamic reaction monitoring

Author

Listed:
  • Borislav Hinkov

    (TU Wien)

  • Florian Pilat

    (TU Wien)

  • Laurin Lux

    (TU Wien)

  • Patricia L. Souza

    (TU Wien
    LabSem-CETUC, Pontifícia Universidade Católica do Rio de Janeiro)

  • Mauro David

    (TU Wien)

  • Andreas Schwaighofer

    (TU Wien)

  • Daniela Ristanić

    (TU Wien)

  • Benedikt Schwarz

    (TU Wien)

  • Hermann Detz

    (TU Wien
    Brno University of Technology)

  • Aaron M. Andrews

    (TU Wien)

  • Bernhard Lendl

    (TU Wien)

  • Gottfried Strasser

    (TU Wien)

Abstract

Mid-infrared spectroscopy is a sensitive and selective technique for probing molecules in the gas or liquid phase. Investigating chemical reactions in bio-medical applications such as drug production is recently gaining particular interest. However, monitoring dynamic processes in liquids is commonly limited to bulky systems and thus requires time-consuming offline analytics. In this work, we show a next-generation, fully-integrated and robust chip-scale sensor for online measurements of molecule dynamics in a liquid solution. Our fingertip-sized device utilizes quantum cascade technology, combining the emitter, sensing section and detector on a single chip. This enables real-time measurements probing only microliter amounts of analyte in an in situ configuration. We demonstrate time-resolved device operation by analyzing temperature-induced conformational changes of the model protein bovine serum albumin in heavy water. Quantitative measurements reveal excellent performance characteristics in terms of sensor linearity, wide coverage of concentrations, extending from 0.075 mg ml−1 to 92 mg ml−1 and a 55-times higher absorbance than state-of-the-art bulky and offline reference systems.

Suggested Citation

  • Borislav Hinkov & Florian Pilat & Laurin Lux & Patricia L. Souza & Mauro David & Andreas Schwaighofer & Daniela Ristanić & Benedikt Schwarz & Hermann Detz & Aaron M. Andrews & Bernhard Lendl & Gottfri, 2022. "A mid-infrared lab-on-a-chip for dynamic reaction monitoring," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-32417-7
    DOI: 10.1038/s41467-022-32417-7
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    References listed on IDEAS

    as
    1. Gustavo Villares & Andreas Hugi & Stéphane Blaser & Jérôme Faist, 2014. "Dual-comb spectroscopy based on quantum-cascade-laser frequency combs," Nature Communications, Nature, vol. 5(1), pages 1-9, December.
    2. Iban Amenabar & Simon Poly & Wiwat Nuansing & Elmar H. Hubrich & Alexander A. Govyadinov & Florian Huth & Roman Krutokhvostov & Lianbing Zhang & Mato Knez & Joachim Heberle & Alexander M. Bittner & Ra, 2013. "Structural analysis and mapping of individual protein complexes by infrared nanospectroscopy," Nature Communications, Nature, vol. 4(1), pages 1-9, December.
    3. Benedikt Schwarz & Peter Reininger & Daniela Ristanić & Hermann Detz & Aaron Maxwell Andrews & Werner Schrenk & Gottfried Strasser, 2014. "Monolithically integrated mid-infrared lab-on-a-chip using plasmonics and quantum cascade structures," Nature Communications, Nature, vol. 5(1), pages 1-7, September.
    4. Andreas Hugi & Gustavo Villares & Stéphane Blaser & H. C. Liu & Jérôme Faist, 2012. "Mid-infrared frequency comb based on a quantum cascade laser," Nature, Nature, vol. 492(7428), pages 229-233, December.
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