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Vibrio cholerae O139 genomes provide a clue to why it may have failed to usher in the eighth cholera pandemic

Author

Listed:
  • Thandavarayan Ramamurthy

    (National Institute of Cholera and Enteric Diseases (NICED))

  • Agila Kumari Pragasam

    (Christian Medical College)

  • Alyce Taylor-Brown

    (Wellcome Genome Campus)

  • Robert C. Will

    (University of Cambridge)

  • Karthick Vasudevan

    (Christian Medical College
    REVA University)

  • Bhabatosh Das

    (Translational Health Science and Technology Institute)

  • Sunil Kumar Srivastava

    (University of Delhi)

  • Goutam Chowdhury

    (National Institute of Cholera and Enteric Diseases (NICED))

  • Asish K. Mukhopadhyay

    (National Institute of Cholera and Enteric Diseases (NICED))

  • Shanta Dutta

    (National Institute of Cholera and Enteric Diseases (NICED))

  • Balaji Veeraraghavan

    (Christian Medical College)

  • Nicholas R. Thomson

    (Wellcome Genome Campus
    London School of Hygiene and Tropical Medicine)

  • Naresh C. Sharma

    (Maharishi Valmiki Infectious Diseases Hospital)

  • Gopinath Balakrish Nair

    (Rajiv Gandhi Centre for Biotechnology)

  • Yoshifumi Takeda

    (National Institute of Infectious Diseases)

  • Amit Ghosh

    (National Institute of Cholera and Enteric Diseases (NICED))

  • Gordon Dougan

    (University of Cambridge)

  • Ankur Mutreja

    (University of Cambridge
    Translational Health Science and Technology Institute)

Abstract

Cholera is a life-threatening infectious disease that remains an important public health issue in several low and middle-income countries. In 1992, a newly identified O139 Vibrio cholerae temporarily displaced the O1 serogroup. No study has been able to answer why the potential eighth cholera pandemic (8CP) causing V. cholerae O139 emerged so successfully and then died out. We conducted a genomic study, including 330 O139 isolates, covering emergence of the serogroup in 1992 through to 2015. We noted two key genomic evolutionary changes that may have been responsible for the disappearance of genetically distinct but temporally overlapping waves (A-C) of O139. Firstly, as the waves progressed, a switch from a homogenous toxin genotype in wave-A to heterogeneous genotypes. Secondly, a gradual loss of antimicrobial resistance (AMR) with the progression of waves. We hypothesize that these two changes contributed to the eventual epidemiological decline of O139.

Suggested Citation

  • Thandavarayan Ramamurthy & Agila Kumari Pragasam & Alyce Taylor-Brown & Robert C. Will & Karthick Vasudevan & Bhabatosh Das & Sunil Kumar Srivastava & Goutam Chowdhury & Asish K. Mukhopadhyay & Shanta, 2022. "Vibrio cholerae O139 genomes provide a clue to why it may have failed to usher in the eighth cholera pandemic," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-31391-4
    DOI: 10.1038/s41467-022-31391-4
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    References listed on IDEAS

    as
    1. Ankur Mutreja & Dong Wook Kim & Nicholas R. Thomson & Thomas R. Connor & Je Hee Lee & Samuel Kariuki & Nicholas J. Croucher & Seon Young Choi & Simon R. Harris & Michael Lebens & Swapan Kumar Niyogi &, 2011. "Evidence for several waves of global transmission in the seventh cholera pandemic," Nature, Nature, vol. 477(7365), pages 462-465, September.
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