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Cross-reactive immunity against the SARS-CoV-2 Omicron variant is low in pediatric patients with prior COVID-19 or MIS-C

Author

Listed:
  • Juanjie Tang

    (Division of Viral Products, Center for Biologics Evaluation and Research (CBER), FDA)

  • Tanya Novak

    (Boston Children’s Hospital
    Harvard Medical School)

  • Julian Hecker

    (Brigham and Women’s Hospital and Harvard Medical School)

  • Gabrielle Grubbs

    (Division of Viral Products, Center for Biologics Evaluation and Research (CBER), FDA)

  • Fatema Tuz Zahra

    (Division of Viral Products, Center for Biologics Evaluation and Research (CBER), FDA)

  • Lorenza Bellusci

    (Division of Viral Products, Center for Biologics Evaluation and Research (CBER), FDA)

  • Sara Pourhashemi

    (Division of Viral Products, Center for Biologics Evaluation and Research (CBER), FDA)

  • Janet Chou

    (Boston Children’s Hospital and Harvard Medical School
    Boston Children’s Hospital, Harvard Medical School)

  • Kristin Moffitt

    (Boston Children’s Hospital and Harvard Medical School
    Boston Children’s Hospital)

  • Natasha B. Halasa

    (Vanderbilt University Medical Center)

  • Stephanie P. Schwartz

    (University of North Carolina at Chapel Hill Children’s Hospital)

  • Tracie C. Walker

    (University of North Carolina at Chapel Hill Children’s Hospital)

  • Keiko M. Tarquinio

    (Emory University School of Medicine, Children’s Healthcare of Atlanta)

  • Matt S. Zinter

    (University of California, San Francisco)

  • Mary A. Staat

    (Cincinnati Children’s Hospital Medical Center)

  • Shira J. Gertz

    (Cooperman Barnabas Medical Center)

  • Natalie Z. Cvijanovich

    (UCSF Benioff Children’s Hospital Oakland)

  • Jennifer E. Schuster

    (Children’s Mercy Kansas City)

  • Laura L. Loftis

    (Baylor College of Medicine)

  • Bria M. Coates

    (Northwestern University Feinberg School of Medicine, Ann & Robert H. Lurie Children’s Hospital of Chicago)

  • Elizabeth H. Mack

    (Medical University of South Carolina)

  • Katherine Irby

    (Arkansas Children’s Hospital)

  • Julie C. Fitzgerald

    (The University of Pennsylvania Perelman School of Medicine)

  • Courtney M. Rowan

    (Indiana University School of Medicine, Riley Hospital for Children)

  • Michele Kong

    (University of Alabama at Birmingham)

  • Heidi R. Flori

    (Mott Children’s Hospital and University of Michigan)

  • Aline B. Maddux

    (University of Colorado School of Medicine and Children’s Hospital Colorado)

  • Steven L. Shein

    (Rainbow Babies and Children’s Hospital)

  • Hillary Crandall

    (University of Utah)

  • Janet R. Hume

    (University of Minnesota Masonic Children’s Hospital)

  • Charlotte V. Hobbs

    (University of Mississippi Medical Center)

  • Adriana H. Tremoulet

    (UCSD School of Medicine)

  • Chisato Shimizu

    (UCSD School of Medicine)

  • Jane C. Burns

    (UCSD School of Medicine)

  • Sabrina R. Chen

    (Boston Children’s Hospital)

  • Hye Kyung Moon

    (Boston Children’s Hospital)

  • Christoph Lange

    (Harvard T.H. Chan School of Public Health)

  • Adrienne G. Randolph

    (Boston Children’s Hospital
    Harvard Medical School
    Boston Children’s Hospital and Harvard Medical School)

  • Surender Khurana

    (Division of Viral Products, Center for Biologics Evaluation and Research (CBER), FDA)

Abstract

Neutralization capacity of antibodies against Omicron after a prior SARS-CoV-2 infection in children and adolescents is not well studied. Therefore, we evaluated virus-neutralizing capacity against SARS-CoV-2 Alpha, Beta, Gamma, Delta and Omicron variants by age-stratified analyses ( 5 years of age. As expected, convalescent pediatric COVID-19 and MIS-C cohorts demonstrate higher neutralization titers than hospitalized acute COVID-19 patients. Overall, children and adolescents show some loss of cross-neutralization against all variants, with the most pronounced loss against Omicron. In contrast to SARS-CoV-2 infection, children vaccinated twice demonstrated higher titers against Alpha, Beta, Gamma, Delta and Omicron. These findings can influence transmission, re-infection and the clinical disease outcome from emerging SARS-CoV-2 variants and supports the need for vaccination in children.

Suggested Citation

  • Juanjie Tang & Tanya Novak & Julian Hecker & Gabrielle Grubbs & Fatema Tuz Zahra & Lorenza Bellusci & Sara Pourhashemi & Janet Chou & Kristin Moffitt & Natasha B. Halasa & Stephanie P. Schwartz & Trac, 2022. "Cross-reactive immunity against the SARS-CoV-2 Omicron variant is low in pediatric patients with prior COVID-19 or MIS-C," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-30649-1
    DOI: 10.1038/s41467-022-30649-1
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    References listed on IDEAS

    as
    1. Masahiro Yoshida & Kaylee B. Worlock & Ni Huang & Rik G. H. Lindeboom & Colin R. Butler & Natsuhiko Kumasaka & Cecilia Dominguez Conde & Lira Mamanova & Liam Bolt & Laura Richardson & Krzysztof Polans, 2022. "Local and systemic responses to SARS-CoV-2 infection in children and adults," Nature, Nature, vol. 602(7896), pages 321-327, February.
    2. Juanjie Tang & Supriya Ravichandran & Youri Lee & Gabrielle Grubbs & Elizabeth M. Coyle & Laura Klenow & Hollie Genser & Hana Golding & Surender Khurana, 2021. "Antibody affinity maturation and plasma IgA associate with clinical outcome in hospitalized COVID-19 patients," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
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    Cited by:

    1. Alexander C. Dowell & Tara Lancaster & Rachel Bruton & Georgina Ireland & Christopher Bentley & Panagiota Sylla & Jianmin Zuo & Sam Scott & Azar Jadir & Jusnara Begum & Thomas Roberts & Christine Step, 2023. "Immunological imprinting of humoral immunity to SARS-CoV-2 in children," Nature Communications, Nature, vol. 14(1), pages 1-9, December.
    2. Lorenza Bellusci & Gabrielle Grubbs & Shaimaa Sait & Lael M. Yonker & Adrienne G. Randolph & Tanya Novak & Takuma Kobayashi & Surender Khurana, 2023. "Neutralization of SARS-CoV-2 Omicron BQ.1, BQ.1.1 and XBB.1 variants following SARS-CoV-2 infection or vaccination in children," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

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