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Social isolation modulates appetite and avoidance behavior via a common oxytocinergic circuit in larval zebrafish

Author

Listed:
  • Caroline L. Wee

    (Harvard University
    Program in Neuroscience, Department of Neurobiology, Harvard Medical School
    Institute of Molecular and Cell Biology)

  • Erin Song

    (Harvard University)

  • Maxim Nikitchenko

    (Harvard University
    Duke University)

  • Kristian J. Herrera

    (Harvard University)

  • Sandy Wong

    (Harvard University)

  • Florian Engert

    (Harvard University)

  • Samuel Kunes

    (Harvard University)

Abstract

Animal brains have evolved to encode social stimuli and transform these representations into advantageous behavioral responses. The commonalities and differences of these representations across species are not well-understood. Here, we show that social isolation activates an oxytocinergic (OXT), nociceptive circuit in the larval zebrafish hypothalamus and that chemical cues released from conspecific animals are potent modulators of this circuit’s activity. We delineate an olfactory to subpallial pathway that transmits chemical social cues to OXT circuitry, where they are transformed into diverse outputs simultaneously regulating avoidance and feeding behaviors. Our data allow us to propose a model through which social stimuli are integrated within a fundamental neural circuit to mediate diverse adaptive behaviours.

Suggested Citation

  • Caroline L. Wee & Erin Song & Maxim Nikitchenko & Kristian J. Herrera & Sandy Wong & Florian Engert & Samuel Kunes, 2022. "Social isolation modulates appetite and avoidance behavior via a common oxytocinergic circuit in larval zebrafish," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-29765-9
    DOI: 10.1038/s41467-022-29765-9
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    References listed on IDEAS

    as
    1. Lukas Anneser & Ivan C. Alcantara & Anja Gemmer & Kristina Mirkes & Soojin Ryu & Erin M. Schuman, 2020. "The neuropeptide Pth2 dynamically senses others via mechanosensation," Nature, Nature, vol. 588(7839), pages 653-657, December.
    2. Constantina Theofanopoulou & Gregory Gedman & James A. Cahill & Cedric Boeckx & Erich D. Jarvis, 2021. "Universal nomenclature for oxytocin–vasotocin ligand and receptor families," Nature, Nature, vol. 592(7856), pages 747-755, April.
    3. Roy Harpaz & Minh Nguyet Nguyen & Armin Bahl & Florian Engert, 2021. "Precise visuomotor transformations underlying collective behavior in larval zebrafish," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
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