IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v13y2022i1d10.1038_s41467-022-29183-x.html
   My bibliography  Save this article

Genetic variation of macronutrient tolerance in Drosophila melanogaster

Author

Listed:
  • E. Havula

    (The University of Sydney
    The University of Sydney
    University of Helsinki)

  • S. Ghazanfar

    (The University of Sydney
    University of Cambridge)

  • N. Lamichane

    (University of Helsinki
    University of Helsinki)

  • D. Francis

    (The University of Sydney)

  • K. Hasygar

    (University of Helsinki
    University of Helsinki)

  • Y. Liu

    (University of Helsinki
    University of Helsinki)

  • L. A. Alton

    (Monash University)

  • J. Johnstone

    (Monash University)

  • E. J. Needham

    (The University of Sydney
    The University of Sydney)

  • T. Pulpitel

    (The University of Sydney)

  • T. Clark

    (The University of Sydney)

  • H. N. Niranjan

    (The University of Sydney)

  • V. Shang

    (The University of Sydney)

  • V. Tong

    (The University of Sydney)

  • N. Jiwnani

    (The University of Sydney)

  • G. Audia

    (The University of Sydney)

  • A. N. Alves

    (Monash University)

  • L. Sylow

    (University of Copenhagen
    University of Copenhagen)

  • C. Mirth

    (Monash University)

  • G. G. Neely

    (The University of Sydney
    The University of Sydney)

  • J. Yang

    (The University of Sydney
    The University of Sydney)

  • V. Hietakangas

    (University of Helsinki
    University of Helsinki)

  • S. J. Simpson

    (The University of Sydney
    The University of Sydney)

  • A. M. Senior

    (The University of Sydney
    The University of Sydney
    The University of Sydney)

Abstract

Carbohydrates, proteins and lipids are essential nutrients to all animals; however, closely related species, populations, and individuals can display dramatic variation in diet. Here we explore the variation in macronutrient tolerance in Drosophila melanogaster using the Drosophila genetic reference panel, a collection of ~200 strains derived from a single natural population. Our study demonstrates that D. melanogaster, often considered a “dietary generalist”, displays marked genetic variation in survival on different diets, notably on high-sugar diet. Our genetic analysis and functional validation identify several regulators of macronutrient tolerance, including CG10960/GLUT8, Pkn and Eip75B. We also demonstrate a role for the JNK pathway in sugar tolerance and de novo lipogenesis. Finally, we report a role for tailless, a conserved orphan nuclear hormone receptor, in regulating sugar metabolism via insulin-like peptide secretion and sugar-responsive CCHamide-2 expression. Our study provides support for the use of nutrigenomics in the development of personalized nutrition.

Suggested Citation

  • E. Havula & S. Ghazanfar & N. Lamichane & D. Francis & K. Hasygar & Y. Liu & L. A. Alton & J. Johnstone & E. J. Needham & T. Pulpitel & T. Clark & H. N. Niranjan & V. Shang & V. Tong & N. Jiwnani & G., 2022. "Genetic variation of macronutrient tolerance in Drosophila melanogaster," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-29183-x
    DOI: 10.1038/s41467-022-29183-x
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-022-29183-x
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-022-29183-x?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Jiro Hirosumi & Gürol Tuncman & Lufen Chang & Cem Z. Görgün & K. Teoman Uysal & Kazuhisa Maeda & Michael Karin & Gökhan S. Hotamisligil, 2002. "A central role for JNK in obesity and insulin resistance," Nature, Nature, vol. 420(6913), pages 333-336, November.
    2. Alejo Efeyan & William C. Comb & David M. Sabatini, 2015. "Nutrient-sensing mechanisms and pathways," Nature, Nature, vol. 517(7534), pages 302-310, January.
    3. Hiroko Ohki-Hamazaki & Kei Watase & Kazutoshi Yamamoto & Hiroo Ogura & Mariko Yamano & Kazuyuki Yamada & Hiroshi Maeno & Junko Imaki & Sakae Kikuyama & Etsuko Wada & Keiji Wada, 1997. "Mice lacking bombesin receptor subtype-3 develop metabolic defects and obesity," Nature, Nature, vol. 390(6656), pages 165-169, November.
    4. Ida Moltke & Niels Grarup & Marit E. Jørgensen & Peter Bjerregaard & Jonas T. Treebak & Matteo Fumagalli & Thorfinn S. Korneliussen & Marianne A. Andersen & Thomas S. Nielsen & Nikolaj T. Krarup & Ane, 2014. "A common Greenlandic TBC1D4 variant confers muscle insulin resistance and type 2 diabetes," Nature, Nature, vol. 512(7513), pages 190-193, August.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Mette K Andersen & Emil Jørsboe & Line Skotte & Kristian Hanghøj & Camilla H Sandholt & Ida Moltke & Niels Grarup & Timo Kern & Yuvaraj Mahendran & Bolette Søborg & Peter Bjerregaard & Christina V L L, 2020. "The derived allele of a novel intergenic variant at chromosome 11 associates with lower body mass index and a favorable metabolic phenotype in Greenlanders," PLOS Genetics, Public Library of Science, vol. 16(1), pages 1-17, January.
    2. Tomas Venit & Oscar Sapkota & Wael Said Abdrabou & Palanikumar Loganathan & Renu Pasricha & Syed Raza Mahmood & Nadine Hosny El Said & Shimaa Sherif & Sneha Thomas & Salah Abdelrazig & Shady Amin & Da, 2023. "Positive regulation of oxidative phosphorylation by nuclear myosin 1 protects cells from metabolic reprogramming and tumorigenesis in mice," Nature Communications, Nature, vol. 14(1), pages 1-24, December.
    3. Nicola Alesi & Elie W. Akl & Damir Khabibullin & Heng-Jia Liu & Anna S. Nidhiry & Emma R. Garner & Harilaos Filippakis & Hilaire C. Lam & Wei Shi & Srinivas R. Viswanathan & Manrico Morroni & Shawn M., 2021. "TSC2 regulates lysosome biogenesis via a non-canonical RAGC and TFEB-dependent mechanism," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    4. Isabel Reinisch & Helene Michenthaler & Alba Sulaj & Elisabeth Moyschewitz & Jelena Krstic & Markus Galhuber & Ruonan Xu & Zina Riahi & Tongtong Wang & Nemanja Vujic & Melina Amor & Riccardo Zenezini , 2024. "Adipocyte p53 coordinates the response to intermittent fasting by regulating adipose tissue immune cell landscape," Nature Communications, Nature, vol. 15(1), pages 1-21, December.
    5. George Rosenberger & Wenxue Li & Mikko Turunen & Jing He & Prem S. Subramaniam & Sergey Pampou & Aaron T. Griffin & Charles Karan & Patrick Kerwin & Diana Murray & Barry Honig & Yansheng Liu & Andrea , 2024. "Network-based elucidation of colon cancer drug resistance mechanisms by phosphoproteomic time-series analysis," Nature Communications, Nature, vol. 15(1), pages 1-27, December.
    6. Olga Kubrak & Takashi Koyama & Nadja Ahrentløv & Line Jensen & Alina Malita & Muhammad T. Naseem & Mette Lassen & Stanislav Nagy & Michael J. Texada & Kenneth V. Halberg & Kim Rewitz, 2022. "The gut hormone Allatostatin C/Somatostatin regulates food intake and metabolic homeostasis under nutrient stress," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    7. Marko Groeger & Koji Matsuo & Emad Heidary Arash & Ashley Pereira & Dounia Guillou & Cindy Pino & Kayque A. Telles-Silva & Jacquelyn J. Maher & Edward C. Hsiao & Holger Willenbring, 2023. "Modeling and therapeutic targeting of inflammation-induced hepatic insulin resistance using human iPSC-derived hepatocytes and macrophages," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    8. Joana Silva & Ferhat Alkan & Sofia Ramalho & Goda Snieckute & Stefan Prekovic & Ana Krotenberg Garcia & Santiago Hernández-Pérez & Rob Kammen & Danielle Barnum & Liesbeth Hoekman & Maarten Altelaar & , 2022. "Ribosome impairment regulates intestinal stem cell identity via ZAKɑ activation," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    9. Matthew J Maley & Andrew P Hunt & Ian B Stewart & Steve H Faulkner & Geoffrey M Minett, 2019. "Passive heating and glycaemic control in non-diabetic and diabetic individuals: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 14(3), pages 1-18, March.
    10. Kibum Kim & Hee Chan Yoo & Byung Gyu Kim & Sulhee Kim & Yulseung Sung & Ina Yoon & Ya Chun Yu & Seung Joon Park & Jong Hyun Kim & Kyungjae Myung & Kwang Yeon Hwang & Sunghoon Kim & Jung Min Han, 2022. "O-GlcNAc modification of leucyl-tRNA synthetase 1 integrates leucine and glucose availability to regulate mTORC1 and the metabolic fate of leucine," Nature Communications, Nature, vol. 13(1), pages 1-19, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-29183-x. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.