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Antibody escape and global spread of SARS-CoV-2 lineage A.27

Author

Listed:
  • Tamara Kaleta

    (University of Freiburg)

  • Lisa Kern

    (University of Freiburg)

  • Samuel Leandro Hong

    (Rega Institute, KU Leuven)

  • Martin Hölzer

    (Robert Koch Institute)

  • Georg Kochs

    (University of Freiburg)

  • Julius Beer

    (University of Freiburg)

  • Daniel Schnepf

    (University of Freiburg)

  • Martin Schwemmle

    (University of Freiburg)

  • Nena Bollen

    (Rega Institute, KU Leuven)

  • Philipp Kolb

    (University of Freiburg)

  • Magdalena Huber

    (University of Freiburg)

  • Svenja Ulferts

    (University of Freiburg)

  • Sebastian Weigang

    (University of Freiburg)

  • Gytis Dudas

    (Gothenburg Global Biodiversity Centre)

  • Alice Wittig

    (Robert Koch Institute
    University of Potsdam)

  • Lena Jaki

    (University of Freiburg)

  • Abdou Padane

    (de Surveillance Epidémiologique et de Formation (IRESSEF))

  • Adamou Lagare

    (Centre de Recherche Médicale et Sanitaire (CERMES))

  • Mounerou Salou

    (Université de Lomé)

  • Egon Anderson Ozer

    (Northwestern University Feinberg School of Medicine)

  • Ndodo Nnaemeka

    (Nigeria Centre for Disease Control)

  • John Kofi Odoom

    (Noguchi Memorial Institute for Medical Research, University of Ghana)

  • Robert Rutayisire

    (Ministry of Health
    Rwanda Biomedical Center)

  • Alia Benkahla

    (Institut Pasteur de Tunis, University of Tunis El Manar)

  • Chantal Akoua-Koffi

    (Centre Hospitalier et Universitaire de Bouaké)

  • Abdoul-Salam Ouedraogo

    (Souro Sanou University Hospital)

  • Etienne Simon-Lorière

    (Institut Pasteur)

  • Vincent Enouf

    (Institut Pasteur)

  • Stefan Kröger

    (Robert Koch Institute)

  • Sébastien Calvignac-Spencer

    (Robert Koch Institute)

  • Guy Baele

    (Rega Institute, KU Leuven)

  • Marcus Panning

    (University of Freiburg)

  • Jonas Fuchs

    (University of Freiburg)

Abstract

In spring 2021, an increasing number of infections was observed caused by the hitherto rarely described SARS-CoV-2 variant A.27 in south-west Germany. From December 2020 to June 2021 this lineage has been detected in 31 countries. Phylogeographic analyses of A.27 sequences obtained from national and international databases reveal a global spread of this lineage through multiple introductions from its inferred origin in Western Africa. Variant A.27 is characterized by a mutational pattern in the spike gene that includes the L18F, L452R and N501Y spike amino acid substitutions found in various variants of concern but lacks the globally dominant D614G. Neutralization assays demonstrate an escape of A.27 from convalescent and vaccine-elicited antibody-mediated immunity. Moreover, the therapeutic monoclonal antibody Bamlanivimab and partially the REGN-COV2 cocktail fail to block infection by A.27. Our data emphasize the need for continued global monitoring of novel lineages because of the independent evolution of new escape mutations.

Suggested Citation

  • Tamara Kaleta & Lisa Kern & Samuel Leandro Hong & Martin Hölzer & Georg Kochs & Julius Beer & Daniel Schnepf & Martin Schwemmle & Nena Bollen & Philipp Kolb & Magdalena Huber & Svenja Ulferts & Sebast, 2022. "Antibody escape and global spread of SARS-CoV-2 lineage A.27," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-28766-y
    DOI: 10.1038/s41467-022-28766-y
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    1. G. Tuba Barut & Nico Joel Halwe & Adriano Taddeo & Jenna N. Kelly & Jacob Schön & Nadine Ebert & Lorenz Ulrich & Christelle Devisme & Silvio Steiner & Bettina Salome Trüeb & Bernd Hoffmann & Inês Bere, 2022. "The spike gene is a major determinant for the SARS-CoV-2 Omicron-BA.1 phenotype," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    2. Lena Jaki & Sebastian Weigang & Lisa Kern & Stefanie Kramme & Antoni G. Wrobel & Andrea B. Grawitz & Philipp Nawrath & Stephen R. Martin & Theo Dähne & Julius Beer & Miriam Disch & Philipp Kolb & Lisa, 2023. "Total escape of SARS-CoV-2 from dual monoclonal antibody therapy in an immunocompromised patient," Nature Communications, Nature, vol. 14(1), pages 1-14, December.

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