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Microalgae-based oral microcarriers for gut microbiota homeostasis and intestinal protection in cancer radiotherapy

Author

Listed:
  • Dongxiao Zhang

    (Zhejiang University School of Medicine
    Zhejiang University)

  • Danni Zhong

    (Zhejiang University School of Medicine
    Zhejiang University)

  • Jiang Ouyang

    (Harvard Medical School)

  • Jian He

    (Zhejiang University)

  • Yuchen Qi

    (Zhejiang University)

  • Wei Chen

    (Harvard Medical School)

  • Xingcai Zhang

    (Harvard University
    Massachusetts Institute of Technology)

  • Wei Tao

    (Harvard Medical School)

  • Min Zhou

    (Zhejiang University School of Medicine
    Zhejiang University
    Zhejiang University
    Zhejiang University)

Abstract

Protecting the whole small intestine from radiation-induced intestinal injury during the radiotherapy of abdominal or pelvic solid tumors remains an unmet clinical need. Amifostine is a promising selective radioprotector for normal tissues. However, its oral application in intestinal radioprotection remains challenging. Herein, we use microalga Spirulina platensis as a microcarrier of Amifostine to construct an oral delivery system. The system shows comprehensive drug accumulation and effective radioprotection in the whole small intestine that is significantly superior to free drug and its enteric capsule, preventing the radiation-induced intestine injury and prolonging the survival without influencing the tumor regression. It also shows benefits on the gut microbiota homeostasis and long-term safety. Based on a readily available natural microcarrier, this work presents a convenient oral delivery system to achieve effective radioprotection for the whole small intestine, providing a competitive strategy with great clinical translation potential.

Suggested Citation

  • Dongxiao Zhang & Danni Zhong & Jiang Ouyang & Jian He & Yuchen Qi & Wei Chen & Xingcai Zhang & Wei Tao & Min Zhou, 2022. "Microalgae-based oral microcarriers for gut microbiota homeostasis and intestinal protection in cancer radiotherapy," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-28744-4
    DOI: 10.1038/s41467-022-28744-4
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    References listed on IDEAS

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    1. Peter J. Turnbaugh & Ruth E. Ley & Michael A. Mahowald & Vincent Magrini & Elaine R. Mardis & Jeffrey I. Gordon, 2006. "An obesity-associated gut microbiome with increased capacity for energy harvest," Nature, Nature, vol. 444(7122), pages 1027-1031, December.
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    Cited by:

    1. Bangfeng Wang & Yiwei Li & Mengfan Zhou & Yulong Han & Mingyu Zhang & Zhaolong Gao & Zetai Liu & Peng Chen & Wei Du & Xingcai Zhang & Xiaojun Feng & Bi-Feng Liu, 2023. "Smartphone-based platforms implementing microfluidic detection with image-based artificial intelligence," Nature Communications, Nature, vol. 14(1), pages 1-18, December.

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