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Different gut microbial communities correlate with efficacy of albendazole-ivermectin against soil-transmitted helminthiases

Author

Listed:
  • Pierre H. H. Schneeberger

    (Helminth Drug Development Unit
    University of Basel)

  • Morgan Gueuning

    (Agroscope, Research Group Molecular Diagnostics, Genomics and Bioinformatics)

  • Sophie Welsche

    (Helminth Drug Development Unit
    University of Basel)

  • Eveline Hürlimann

    (Helminth Drug Development Unit
    University of Basel)

  • Julian Dommann

    (Helminth Drug Development Unit
    University of Basel)

  • Cécile Häberli

    (Helminth Drug Development Unit
    University of Basel)

  • Jürg E. Frey

    (Agroscope, Research Group Molecular Diagnostics, Genomics and Bioinformatics)

  • Somphou Sayasone

    (University of Basel
    Lao Tropical and Public Health Institute)

  • Jennifer Keiser

    (Helminth Drug Development Unit
    University of Basel)

Abstract

Soil-transmitted helminth infections represent a large burden with over a quarter of the world’s population at risk. Low cure rates are observed with standard of care (albendazole); therefore, a more effective combination therapy (albendazole and ivermectin) is being investigated but showed variable treatment efficacies without evidence of intrinsic parasite resistance. Here, we analyzed the microbiome of Trichuris trichiura and hookworm-infected patients and found an association of different enterotypes with treatment efficacy. 80 T. trichiura-infected patients with hookworm co-infections from Pak-Khan, Laos, received either albendazole (n = 41) or albendazole and ivermectin combination therapy (n = 39). Pre-/post-treatment stool samples were collected to monitor treatment efficacy and microbial communities were profiled using 16S rRNA gene sequencing, qPCR, and shotgun sequencing. We identified three bacterial enterotypes and show that pre-treatment enterotype is associated with efficacy of the combination treatment for both T. trichiura (CRET1 = 5.8%; CRET2 = 16.6%; CRET3 = 68.8%) and hookworm (CRET1 = 31.3%; CRET2 = 16.6%; CRET3 = 78.6%). This study shows that pre-treatment enterotype enables predicting treatment outcome of combination therapy for T. trichiura and hookworm infections. Trial registration: ClinicalTrials.gov, NCT03527732. Registered 17 May 2018, https://clinicaltrials.gov/ct2/show/NCT03527732 .

Suggested Citation

  • Pierre H. H. Schneeberger & Morgan Gueuning & Sophie Welsche & Eveline Hürlimann & Julian Dommann & Cécile Häberli & Jürg E. Frey & Somphou Sayasone & Jennifer Keiser, 2022. "Different gut microbial communities correlate with efficacy of albendazole-ivermectin against soil-transmitted helminthiases," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-28658-1
    DOI: 10.1038/s41467-022-28658-1
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    References listed on IDEAS

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    1. Fionn Murtagh & Pierre Legendre, 2014. "Ward’s Hierarchical Agglomerative Clustering Method: Which Algorithms Implement Ward’s Criterion?," Journal of Classification, Springer;The Classification Society, vol. 31(3), pages 274-295, October.
    2. Michael Zimmermann & Maria Zimmermann-Kogadeeva & Rebekka Wegmann & Andrew L. Goodman, 2019. "Mapping human microbiome drug metabolism by gut bacteria and their genes," Nature, Nature, vol. 570(7762), pages 462-467, June.
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