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PEBP balances apoptosis and autophagy in whitefly upon arbovirus infection

Author

Listed:
  • Shifan Wang

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Huijuan Guo

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Keyan Zhu-Salzman

    (Texas A&M University)

  • Feng Ge

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences
    Shandong Academy of Agriculture Sciences)

  • Yucheng Sun

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

Abstract

Apoptosis and autophagy are two common forms of programmed cell death (PCD) used by host organisms to fight against virus infection. PCD in arthropod vectors can be manipulated by arboviruses, leading to arbovirus-vector coexistence, although the underlying mechanism is largely unknown. In this study, we find that coat protein (CP) of an insect-borne plant virus TYLCV directly interacts with a phosphatidylethanolamine-binding protein (PEBP) in its vector whitefly to downregulate MAPK signaling cascade. As a result, apoptosis is activated in the whitefly increasing viral load. Simultaneously, the PEBP4-CP interaction releases ATG8, a hallmark of autophagy initiation, which reduces arbovirus levels. Furthermore, apoptosis-promoted virus amplification is prevented by agonist-induced autophagy, whereas the autophagy-suppressed virus load is unaffected by manipulating apoptosis, suggesting that the viral load is predominantly determined by autophagy rather than by apoptosis. Our results demonstrate that a mild intracellular immune response including balanced apoptosis and autophagy might facilitate arbovirus preservation within its whitefly insect vector.

Suggested Citation

  • Shifan Wang & Huijuan Guo & Keyan Zhu-Salzman & Feng Ge & Yucheng Sun, 2022. "PEBP balances apoptosis and autophagy in whitefly upon arbovirus infection," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-28500-8
    DOI: 10.1038/s41467-022-28500-8
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    1. Bertsy Goic & Kenneth A. Stapleford & Lionel Frangeul & Aurélien J. Doucet & Valérie Gausson & Hervé Blanc & Nidia Schemmel-Jofre & Gael Cristofari & Louis Lambrechts & Marco Vignuzzi & Maria-Carla Sa, 2016. "Virus-derived DNA drives mosquito vector tolerance to arboviral infection," Nature Communications, Nature, vol. 7(1), pages 1-10, November.
    2. Kam Yeung & Thomas Seitz & Shengfeng Li & Petra Janosch & Brian McFerran & Christian Kaiser & Frances Fee & Kostas D. Katsanakis & David W. Rose & Harald Mischak & John M. Sedivy & Walter Kolch, 1999. "Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP," Nature, Nature, vol. 401(6749), pages 173-177, September.
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