IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v12y2021i1d10.1038_s41467-021-27064-3.html
   My bibliography  Save this article

Pre-existing immunity and vaccine history determine hemagglutinin-specific CD4 T cell and IgG response following seasonal influenza vaccination

Author

Listed:
  • Katharina Wild

    (Medical Center – University of Freiburg
    University of Freiburg
    University of Freiburg)

  • Maike Smits

    (Medical Center – University of Freiburg
    University of Freiburg
    University of Freiburg)

  • Saskia Killmer

    (Medical Center – University of Freiburg
    University of Freiburg)

  • Shirin Strohmeier

    (Icahn School of Medicine at Mount Sinai)

  • Christoph Neumann-Haefelin

    (Medical Center – University of Freiburg
    University of Freiburg)

  • Bertram Bengsch

    (Medical Center – University of Freiburg
    University of Freiburg
    University of Freiburg)

  • Florian Krammer

    (Icahn School of Medicine at Mount Sinai)

  • Martin Schwemmle

    (University of Freiburg)

  • Maike Hofmann

    (Medical Center – University of Freiburg
    University of Freiburg)

  • Robert Thimme

    (Medical Center – University of Freiburg
    University of Freiburg)

  • Katharina Zoldan

    (Medical Center – University of Freiburg
    University of Freiburg)

  • Tobias Boettler

    (Medical Center – University of Freiburg
    University of Freiburg)

Abstract

Effectiveness of seasonal influenza vaccination varies between individuals and might be affected by vaccination history among other factors. Here we show, by monitoring frequencies of CD4 T cells specific to the conserved hemagglutinin epitope HA118-132 and titres of IgG against the corresponding recombinant hemagglutinin protein, that antigen-specific CD4 T cell and antibody responses are closely linked to pre-existing immunity and vaccine history. Upon immunization, a strong early reaction is observed in all vaccine naïve participants and also in vaccine experienced individuals who have not received the respective seasonal vaccine in the previous year. This response is characterized by HA118-132 specific CD4 T cells with a follicular helper T cell phenotype and by ascending titers of hemagglutinin-specific antibodies from baseline to day 28 following vaccination. This trend was observed in only a proportion of those participants who received the seasonal vaccine the year preceding the study. Regardless of history, levels of pre-existing antibodies and CD127 expression on CD4 T cells at baseline were the strongest predictors of robust early response. Thus, both pre-existing immunity and vaccine history contribute to the response to seasonal influenza vaccines.

Suggested Citation

  • Katharina Wild & Maike Smits & Saskia Killmer & Shirin Strohmeier & Christoph Neumann-Haefelin & Bertram Bengsch & Florian Krammer & Martin Schwemmle & Maike Hofmann & Robert Thimme & Katharina Zoldan, 2021. "Pre-existing immunity and vaccine history determine hemagglutinin-specific CD4 T cell and IgG response following seasonal influenza vaccination," Nature Communications, Nature, vol. 12(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-27064-3
    DOI: 10.1038/s41467-021-27064-3
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-021-27064-3
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-021-27064-3?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Hannes Uchtenhagen & Cliff Rims & Gabriele Blahnik & I-Ting Chow & William W. Kwok & Jane H. Buckner & Eddie A. James, 2016. "Efficient ex vivo analysis of CD4+ T-cell responses using combinatorial HLA class II tetramer staining," Nature Communications, Nature, vol. 7(1), pages 1-12, November.
    2. K. Kai McKinstry & Tara M. Strutt & Bianca Bautista & Wenliang Zhang & Yi Kuang & Andrea M. Cooper & Susan L. Swain, 2014. "Effector CD4 T-cell transition to memory requires late cognate interactions that induce autocrine IL-2," Nature Communications, Nature, vol. 5(1), pages 1-12, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Eddie A. James & V. Michael Holers & Radhika Iyer & E. Barton Prideaux & Navin L. Rao & Cliff Rims & Virginia S. Muir & Sylvia E. Posso & Michelle S. Bloom & Amin Zia & Serra E. Elliott & Julia Z. Ada, 2023. "Multifaceted immune dysregulation characterizes individuals at-risk for rheumatoid arthritis," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    2. Anja W. Olsen & Ida Rosenkrands & Christina S. Jacobsen & Hannah M. Cheeseman & Max P. Kristiansen & Jes Dietrich & Robin J. Shattock & Frank Follmann, 2024. "Immune signature of Chlamydia vaccine CTH522/CAF®01 translates from mouse-to-human and induces durable protection in mice," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    3. Dingxi Zhou & Mariana Borsa & Daniel J. Puleston & Susanne Zellner & Jesusa Capera & Sharon Sanderson & Martina Schifferer & Svenja S. Hester & Xin Ge & Roman Fischer & Luke Jostins & Christian Behren, 2022. "Mapping autophagosome contents identifies interleukin-7 receptor-α as a key cargo modulating CD4+ T cell proliferation," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-27064-3. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.