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Tracking Brownian motion in three dimensions and characterization of individual nanoparticles using a fiber-based high-finesse microcavity

Author

Listed:
  • Larissa Kohler

    (Physikalisches Institut)

  • Matthias Mader

    (Ludwig-Maximilians-Universität
    Max-Planck-Institut für Quantenoptik)

  • Christian Kern

    (Institut für Angewandte Physik
    Institut für Nanotechnologie)

  • Martin Wegener

    (Institut für Angewandte Physik
    Institut für Nanotechnologie)

  • David Hunger

    (Physikalisches Institut
    Institut für QuantenMaterialien und Technologien)

Abstract

The dynamics of nanosystems in solution contain a wealth of information with relevance for diverse fields ranging from materials science to biology and biomedical applications. When nanosystems are marked with fluorophores or strong scatterers, it is possible to track their position and reveal internal motion with high spatial and temporal resolution. However, markers can be toxic, expensive, or change the object’s intrinsic properties. Here, we simultaneously measure dispersive frequency shifts of three transverse modes of a high-finesse microcavity to obtain the three-dimensional path of unlabeled SiO2 nanospheres with 300 μs temporal and down to 8 nm spatial resolution. This allows us to quantitatively determine properties such as the polarizability, hydrodynamic radius, and effective refractive index. The fiber-based cavity is integrated in a direct-laser-written microfluidic device that enables the precise control of the fluid with ultra-small sample volumes. Our approach enables quantitative nanomaterial characterization and the analysis of biomolecular motion at high bandwidth.

Suggested Citation

  • Larissa Kohler & Matthias Mader & Christian Kern & Martin Wegener & David Hunger, 2021. "Tracking Brownian motion in three dimensions and characterization of individual nanoparticles using a fiber-based high-finesse microcavity," Nature Communications, Nature, vol. 12(1), pages 1-7, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-26719-5
    DOI: 10.1038/s41467-021-26719-5
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    References listed on IDEAS

    as
    1. Matthias Mader & Jakob Reichel & Theodor W. Hänsch & David Hunger, 2015. "A scanning cavity microscope," Nature Communications, Nature, vol. 6(1), pages 1-7, November.
    2. Marek Piliarik & Vahid Sandoghdar, 2014. "Direct optical sensing of single unlabelled proteins and super-resolution imaging of their binding sites," Nature Communications, Nature, vol. 5(1), pages 1-8, December.
    3. Evan P. Perillo & Yen-Liang Liu & Khang Huynh & Cong Liu & Chao-Kai Chou & Mien-Chie Hung & Hsin-Chih Yeh & Andrew K. Dunn, 2015. "Deep and high-resolution three-dimensional tracking of single particles using nonlinear and multiplexed illumination," Nature Communications, Nature, vol. 6(1), pages 1-8, November.
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    Cited by:

    1. Torsten Wieduwilt & Ronny Förster & Mona Nissen & Jens Kobelke & Markus A. Schmidt, 2023. "Characterization of diffusing sub-10 nm nano-objects using single anti-resonant element optical fibers," Nature Communications, Nature, vol. 14(1), pages 1-7, December.

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