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Antibody-mediated disruption of the SARS-CoV-2 spike glycoprotein

Author

Listed:
  • Antoni G. Wrobel

    (Francis Crick Institute)

  • Donald J. Benton

    (Francis Crick Institute)

  • Saira Hussain

    (Francis Crick Institute)

  • Ruth Harvey

    (Francis Crick Institute)

  • Stephen R. Martin

    (Francis Crick Institute)

  • Chloë Roustan

    (Francis Crick Institute)

  • Peter B. Rosenthal

    (Francis Crick Institute)

  • John J. Skehel

    (Francis Crick Institute)

  • Steven J. Gamblin

    (Francis Crick Institute)

Abstract

The CR3022 antibody, selected from a group of SARS-CoV monoclonal antibodies for its ability to cross-react with SARS-CoV-2, has been examined for its ability to bind to the ectodomain of the SARS-CoV-2 spike glycoprotein. Using cryo-electron microscopy we show that antibody binding requires rearrangements in the S1 domain that result in dissociation of the spike.

Suggested Citation

  • Antoni G. Wrobel & Donald J. Benton & Saira Hussain & Ruth Harvey & Stephen R. Martin & Chloë Roustan & Peter B. Rosenthal & John J. Skehel & Steven J. Gamblin, 2020. "Antibody-mediated disruption of the SARS-CoV-2 spike glycoprotein," Nature Communications, Nature, vol. 11(1), pages 1-5, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-19146-5
    DOI: 10.1038/s41467-020-19146-5
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    Cited by:

    1. Oskar Staufer & Kapil Gupta & Jochen Estebano Hernandez Bücher & Fabian Kohler & Christian Sigl & Gunjita Singh & Kate Vasileiou & Ana Yagüe Relimpio & Meline Macher & Sebastian Fabritz & Hendrik Diet, 2022. "Synthetic virions reveal fatty acid-coupled adaptive immunogenicity of SARS-CoV-2 spike glycoprotein," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    2. Andrew C. Hunt & Bastian Vögeli & Ahmed O. Hassan & Laura Guerrero & Weston Kightlinger & Danielle J. Yoesep & Antje Krüger & Madison DeWinter & Michael S. Diamond & Ashty S. Karim & Michael C. Jewett, 2023. "A rapid cell-free expression and screening platform for antibody discovery," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    3. David Hueting & Karen Schriever & Rui Sun & Stelios Vlachiotis & Fanglei Zuo & Likun Du & Helena Persson & Camilla Hofström & Mats Ohlin & Karin Walldén & Marcus Buggert & Lennart Hammarström & Harold, 2023. "Design, structure and plasma binding of ancestral β-CoV scaffold antigens," Nature Communications, Nature, vol. 14(1), pages 1-14, December.

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