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Excitatory VTA to DH projections provide a valence signal to memory circuits

Author

Listed:
  • Yuan Han

    (Northwestern University
    Xuzhou Medical University)

  • Yi Zhang

    (Northwestern University
    University of Missouri)

  • Haram Kim

    (Northwestern University)

  • Viktoriya S. Grayson

    (Northwestern University)

  • Vladimir Jovasevic

    (Northwestern University)

  • Wenjie Ren

    (Northwestern University)

  • Maria V. Centeno

    (Northwestern University)

  • Anita L. Guedea

    (Northwestern University)

  • Mariah A. A. Meyer

    (Northwestern University)

  • Yixin Wu

    (Northwestern University)

  • Philipp Gutruf

    (Northwestern University
    The University of Arizona)

  • Dalton J. Surmeier

    (Northwestern University)

  • Can Gao

    (Xuzhou Medical University)

  • Marco Martina

    (Northwestern University)

  • Apkar V. Apkarian

    (Northwestern University)

  • John A. Rogers

    (Northwestern University)

  • Jelena Radulovic

    (Northwestern University)

Abstract

The positive or negative value (valence) of past experiences is normally integrated into neuronal circuits that encode episodic memories and plays an important role in guiding behavior. Here, we show, using mouse behavioral models, that glutamatergic afferents from the ventral tegmental area to the dorsal hippocampus (VTA→DH) signal negative valence to memory circuits, leading to the formation of fear-inducing context memories and to context-specific reinstatement of fear. To a lesser extent, these projections also contributed to opioid-induced place preference, suggesting a role in signaling positive valence as well, and thus a lack of dedicated polarity. Manipulations of VTA terminal activity were more effective in females and paralleled by sex differences in glutamatergic signaling. By prioritizing retrieval of negative and positive over neutral memories, the VTA→DH circuit can facilitate the selection of adaptive behaviors when current and past experiences are valence congruent.

Suggested Citation

  • Yuan Han & Yi Zhang & Haram Kim & Viktoriya S. Grayson & Vladimir Jovasevic & Wenjie Ren & Maria V. Centeno & Anita L. Guedea & Mariah A. A. Meyer & Yixin Wu & Philipp Gutruf & Dalton J. Surmeier & Ca, 2020. "Excitatory VTA to DH projections provide a valence signal to memory circuits," Nature Communications, Nature, vol. 11(1), pages 1-14, December.
  • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-15035-z
    DOI: 10.1038/s41467-020-15035-z
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    Cited by:

    1. Sang Hyun Sung & Tae Jin Kim & Hyera Shin & Tae Hong Im & Keon Jae Lee, 2022. "Simultaneous emulation of synaptic and intrinsic plasticity using a memristive synapse," Nature Communications, Nature, vol. 13(1), pages 1-12, December.

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