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Retention of paternal DNA methylome in the developing zebrafish germline

Author

Listed:
  • Ksenia Skvortsova

    (Garvan Institute of Medical Research)

  • Katsiaryna Tarbashevich

    (University of Münster)

  • Martin Stehling

    (Max-Planck-Institute for Molecular Biomedicine)

  • Ryan Lister

    (The University of Western Australia
    Harry Perkins Institute of Medical Research)

  • Manuel Irimia

    (The Barcelona Institute for Science and Technology
    Universitat Pompeu Fabra (UPF)
    ICREA)

  • Erez Raz

    (University of Münster)

  • Ozren Bogdanovic

    (Garvan Institute of Medical Research
    University of New South Wales)

Abstract

Two waves of DNA methylation reprogramming occur during mammalian embryogenesis; during preimplantation development and during primordial germ cell (PGC) formation. However, it is currently unclear how evolutionarily conserved these processes are. Here we characterise the DNA methylomes of zebrafish PGCs at four developmental stages and identify retention of paternal epigenetic memory, in stark contrast to the findings in mammals. Gene expression profiling of zebrafish PGCs at the same developmental stages revealed that the embryonic germline is defined by a small number of markers that display strong developmental stage-specificity and that are independent of DNA methylation-mediated regulation. We identified promoters that are specifically targeted by DNA methylation in somatic and germline tissues during vertebrate embryogenesis and that are frequently misregulated in human cancers. Together, these detailed methylome and transcriptome maps of the zebrafish germline provide insight into vertebrate DNA methylation reprogramming and enhance our understanding of the relationships between germline fate acquisition and oncogenesis.

Suggested Citation

  • Ksenia Skvortsova & Katsiaryna Tarbashevich & Martin Stehling & Ryan Lister & Manuel Irimia & Erez Raz & Ozren Bogdanovic, 2019. "Retention of paternal DNA methylome in the developing zebrafish germline," Nature Communications, Nature, vol. 10(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-10895-6
    DOI: 10.1038/s41467-019-10895-6
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    Cited by:

    1. Allegra Angeloni & Skye Fissette & Deniz Kaya & Jillian M. Hammond & Hasindu Gamaarachchi & Ira W. Deveson & Robert J. Klose & Weiming Li & Xiaotian Zhang & Ozren Bogdanovic, 2024. "Extensive DNA methylome rearrangement during early lamprey embryogenesis," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    2. Donna M. Bond & Oscar Ortega-Recalde & Melanie K. Laird & Takashi Hayakawa & Kyle S. Richardson & Finlay.C. B. Reese & Bruce Kyle & Brooke E. McIsaac-Williams & Bruce C. Robertson & Yolanda Heezik & A, 2023. "The admixed brushtail possum genome reveals invasion history in New Zealand and novel imprinted genes," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

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