IDEAS home Printed from https://ideas.repec.org/a/gam/jsusta/v14y2022i7p3896-d779801.html
   My bibliography  Save this article

SARS-CoV-2 Dynamics in the Mucus Layer of the Human Upper Respiratory Tract Based on Host–Cell Dynamics

Author

Listed:
  • Hanyu Li

    (Interdisciplinary Graduate School of Engineering Sciences, Kyushu University, Fukuoka 816-8580, Japan)

  • Kazuki Kuga

    (Faculty of Engineering Sciences, Kyushu University, Fukuoka 816-8580, Japan)

  • Kazuhide Ito

    (Faculty of Engineering Sciences, Kyushu University, Fukuoka 816-8580, Japan)

Abstract

A thorough understanding of the inhalation dynamics of infectious aerosols indoors and infection dynamics within the host by inhaled viruses such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) plays an important role in the assessment and control of infection risks indoors. Here, by combining computational fluid–particle dynamics (CFPD) and host–cell dynamics (HCD), SARS-CoV-2 infection dynamics in the mucus layer of the human upper airway were studied. To reproduce the diffusive and convective transport of the virus in the nasal cavity–nasopharynx by mucociliary motion, a three-dimensional (3D)-shell model with a mucus layer was developed. The initial virus concentrations for HCD calculation were estimated based on the deposition distribution of droplets with representative sizes analyzed by CFPD. To develop a new HCD model, the target-cell-limited model was integrated with the convection–diffusion equation. Additionally, the sensitivity of the infection rate β to the infection dynamics was systematically investigated. The results showed that the time series of SARS-CoV-2 concentration in the mucus layer strongly depended on diffusion, convection, and β. Although the SARS-CoV-2 dynamics obtained here have not been verified by corresponding clinical data, they can preliminarily reveal its transmission mode in the upper airway, which will contribute to the prevention and treatment of coronavirus disease 2019.

Suggested Citation

  • Hanyu Li & Kazuki Kuga & Kazuhide Ito, 2022. "SARS-CoV-2 Dynamics in the Mucus Layer of the Human Upper Respiratory Tract Based on Host–Cell Dynamics," Sustainability, MDPI, vol. 14(7), pages 1-18, March.
    • Handle: RePEc:gam:jsusta:v:14:y:2022:i:7:p:3896-:d:779801
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/2071-1050/14/7/3896/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/2071-1050/14/7/3896/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Roman Wölfel & Victor M. Corman & Wolfgang Guggemos & Michael Seilmaier & Sabine Zange & Marcel A. Müller & Daniela Niemeyer & Terry C. Jones & Patrick Vollmar & Camilla Rothe & Michael Hoelscher & To, 2020. "Author Correction: Virological assessment of hospitalized patients with COVID-2019," Nature, Nature, vol. 588(7839), pages 35-35, December.
    2. Stephen M Kissler & Joseph R Fauver & Christina Mack & Scott W Olesen & Caroline Tai & Kristin Y Shiue & Chaney C Kalinich & Sarah Jednak & Isabel M Ott & Chantal B F Vogels & Jay Wohlgemuth & James W, 2021. "Viral dynamics of acute SARS-CoV-2 infection and applications to diagnostic and public health strategies," PLOS Biology, Public Library of Science, vol. 19(7), pages 1-17, July.
    3. Roman Wölfel & Victor M. Corman & Wolfgang Guggemos & Michael Seilmaier & Sabine Zange & Marcel A. Müller & Daniela Niemeyer & Terry C. Jones & Patrick Vollmar & Camilla Rothe & Michael Hoelscher & To, 2020. "Virological assessment of hospitalized patients with COVID-2019," Nature, Nature, vol. 581(7809), pages 465-469, May.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Anna Maria Cattelan & Lolita Sasset & Federico Zabeo & Anna Ferrari & Lucia Rossi & Maria Mazzitelli & Silvia Cocchio & Vincenzo Baldo, 2022. "Rapid Antigen Test LumiraDx TM vs. Real Time Polymerase Chain Reaction for the Diagnosis of SARS-CoV-2 Infection: A Retrospective Cohort Study," IJERPH, MDPI, vol. 19(7), pages 1-12, March.
    2. Tobias Schlager & Ashley V. Whillans, 2022. "People underestimate the probability of contracting the coronavirus from friends," Palgrave Communications, Palgrave Macmillan, vol. 9(1), pages 1-11, December.
    3. Joseph Pateras & Preetam Ghosh, 2022. "A Computational Framework for Exploring SARS-CoV-2 Pharmacodynamic Dose and Timing Regimes," Mathematics, MDPI, vol. 10(20), pages 1-12, October.
    4. Marta Baselga & Juan J. Alba & Alberto J. Schuhmacher, 2022. "The Control of Metabolic CO 2 in Public Transport as a Strategy to Reduce the Transmission of Respiratory Infectious Diseases," IJERPH, MDPI, vol. 19(11), pages 1-19, May.
    5. Lisa Cariani & Beatrice Silvia Orena & Federico Ambrogi & Simone Gambazza & Anna Maraschini & Antonella Dodaro & Massimo Oggioni & Annarosa Orlandi & Alessia Pirrone & Sara Uceda Renteria & Mara Berna, 2020. "Time Length of Negativization and Cycle Threshold Values in 182 Healthcare Workers with Covid-19 in Milan, Italy: An Observational Cohort Study," IJERPH, MDPI, vol. 17(15), pages 1-10, July.
    6. Dapeng Li & David R. Martinez & Alexandra Schäfer & Haiyan Chen & Maggie Barr & Laura L. Sutherland & Esther Lee & Robert Parks & Dieter Mielke & Whitney Edwards & Amanda Newman & Kevin W. Bock & Mahn, 2022. "Breadth of SARS-CoV-2 neutralization and protection induced by a nanoparticle vaccine," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    7. Susanna Esposito & Federico Marchetti & Marcello Lanari & Fabio Caramelli & Alessandro De Fanti & Gianluca Vergine & Lorenzo Iughetti & Martina Fornaro & Agnese Suppiej & Stefano Zona & Andrea Pession, 2021. "COVID-19 Management in the Pediatric Age: Consensus Document of the COVID-19 Working Group in Paediatrics of the Emilia-Romagna Region (RE-CO-Ped), Italy," IJERPH, MDPI, vol. 18(8), pages 1-29, April.
    8. Ramon Roozendaal & Laura Solforosi & Daniel J. Stieh & Jan Serroyen & Roel Straetemans & Anna Dari & Muriel Boulton & Frank Wegmann & Sietske K. Rosendahl Huber & Joan E. M. van der Lubbe & Jenny Hend, 2021. "SARS-CoV-2 binding and neutralizing antibody levels after Ad26.COV2.S vaccination predict durable protection in rhesus macaques," Nature Communications, Nature, vol. 12(1), pages 1-10, December.
    9. Shengwei Zhu & Tong Lin & John D. Spengler & Jose Guillermo Cedeño Laurent & Jelena Srebric, 2022. "The Influence of Plastic Barriers on Aerosol Infection Risk during Airport Security Checks," Sustainability, MDPI, vol. 14(18), pages 1-14, September.
    10. Sasha Harris-Lovett & Kara L. Nelson & Paloma Beamer & Heather N. Bischel & Aaron Bivins & Andrea Bruder & Caitlyn Butler & Todd D. Camenisch & Susan K. De Long & Smruthi Karthikeyan & David A. Larsen, 2021. "Wastewater Surveillance for SARS-CoV-2 on College Campuses: Initial Efforts, Lessons Learned, and Research Needs," IJERPH, MDPI, vol. 18(9), pages 1-20, April.
    11. Maria de Lourdes Aguiar-Oliveira & Aline Campos & Aline R. Matos & Caroline Rigotto & Adriana Sotero-Martins & Paulo F. P. Teixeira & Marilda M. Siqueira, 2020. "Wastewater-Based Epidemiology (WBE) and Viral Detection in Polluted Surface Water: A Valuable Tool for COVID-19 Surveillance—A Brief Review," IJERPH, MDPI, vol. 17(24), pages 1-19, December.
    12. Rabih Ghostine & Mohamad Gharamti & Sally Hassrouny & Ibrahim Hoteit, 2021. "Mathematical Modeling of Immune Responses against SARS-CoV-2 Using an Ensemble Kalman Filter," Mathematics, MDPI, vol. 9(19), pages 1-13, September.
    13. Chih-Chia Hsieh & Chih-Hao Lin & William Yu Chung Wang & David J. Pauleen & Jengchung Victor Chen, 2020. "The Outcome and Implications of Public Precautionary Measures in Taiwan–Declining Respiratory Disease Cases in the COVID-19 Pandemic," IJERPH, MDPI, vol. 17(13), pages 1-10, July.
    14. Abdin, Adam F. & Fang, Yi-Ping & Caunhye, Aakil & Alem, Douglas & Barros, Anne & Zio, Enrico, 2023. "An optimization model for planning testing and control strategies to limit the spread of a pandemic – The case of COVID-19," European Journal of Operational Research, Elsevier, vol. 304(1), pages 308-324.
    15. Jos Lelieveld & Frank Helleis & Stephan Borrmann & Yafang Cheng & Frank Drewnick & Gerald Haug & Thomas Klimach & Jean Sciare & Hang Su & Ulrich Pöschl, 2020. "Model Calculations of Aerosol Transmission and Infection Risk of COVID-19 in Indoor Environments," IJERPH, MDPI, vol. 17(21), pages 1-18, November.
    16. Marziah Hashimi & T. Andrew Sebrell & Jodi F. Hedges & Deann Snyder & Katrina N. Lyon & Stephanie D. Byrum & Samuel G. Mackintosh & Dan Crowley & Michelle D. Cherne & David Skwarchuk & Amanda Robison , 2023. "Antiviral responses in a Jamaican fruit bat intestinal organoid model of SARS-CoV-2 infection," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    17. Antonella De Donno & Giambattista Lobreglio & Alessandra Panico & Tiziana Grassi & Francesco Bagordo & Maria Pia Bozzetti & Serafina Massari & Luisa Siculella & Fabrizio Damiano & Francesco Guerra & M, 2021. "IgM and IgG Profiles Reveal Peculiar Features of Humoral Immunity Response to SARS-CoV-2 Infection," IJERPH, MDPI, vol. 18(3), pages 1-15, February.
    18. Andrea Mancusi & Federico Capuano & Santa Girardi & Orlandina Di Maro & Elisabetta Suffredini & Denise Di Concilio & Lucia Vassallo & Maria Concetta Cuomo & Maria Tafuro & Daniel Signorelli & Andrea P, 2022. "Detection of SARS-CoV-2 RNA in Bivalve Mollusks by Droplet Digital RT-PCR (dd RT-PCR)," IJERPH, MDPI, vol. 19(2), pages 1-13, January.
    19. Xiaoli Wang & Lin Fan & Ziqiang Dai & Li Li & Xianliang Wang, 2022. "Predictive Model for National Minimal CFR during Spontaneous Initial Outbreak of Emerging Infectious Disease: Lessons from COVID-19 Pandemic in 214 Nations and Regions," IJERPH, MDPI, vol. 20(1), pages 1-16, December.
    20. Niklas Kappelt & Hugo Savill Russell & Szymon Kwiatkowski & Alireza Afshari & Matthew Stanley Johnson, 2021. "Correlation of Respiratory Aerosols and Metabolic Carbon Dioxide," Sustainability, MDPI, vol. 13(21), pages 1-11, November.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jsusta:v:14:y:2022:i:7:p:3896-:d:779801. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.