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Mapping the Glymphatic Pathway Using Imaging Advances

Author

Listed:
  • Rajvi N. Thakkar

    (College of Medicine, University of Florida, Gainesville, FL 32610, USA)

  • Ivelina P. Kioutchoukova

    (College of Medicine, University of Florida, Gainesville, FL 32610, USA)

  • Ian Griffin

    (College of Medicine, University of Florida, Gainesville, FL 32610, USA)

  • Devon T. Foster

    (College of Medicine, Florida International University, Miami, FL 33199, USA)

  • Pratiksha Sharma

    (Thermo Fisher Scientific Inc., Boston, MA 02210, USA)

  • Eduardo Molina Valero

    (College of Medicine, University of Florida, Gainesville, FL 32610, USA)

  • Brandon Lucke-Wold

    (Department of Neurosurgery, University of Florida, 1600 SW Archer Rd., Gainesville, FL 32610, USA)

Abstract

The glymphatic system is a newly discovered waste-clearing system that is analogous to the lymphatic system in our central nervous system. Furthermore, disruption in the glymphatic system has also been associated with many neurodegenerative disorders (e.g., Alzheimer’s disease), traumatic brain injury, and subarachnoid hemorrhage. Thus, understanding the function and structure of this system can play a key role in researching the progression and prognoses of these diseases. In this review article, we discuss the current ways to map the glymphatic system and address the advances being made in preclinical mapping. As mentioned, the concept of the glymphatic system is relatively new, and thus, more research needs to be conducted in order to therapeutically intervene via this system.

Suggested Citation

  • Rajvi N. Thakkar & Ivelina P. Kioutchoukova & Ian Griffin & Devon T. Foster & Pratiksha Sharma & Eduardo Molina Valero & Brandon Lucke-Wold, 2023. "Mapping the Glymphatic Pathway Using Imaging Advances," J, MDPI, vol. 6(3), pages 1-15, August.
    • Handle: RePEc:gam:jjopen:v:6:y:2023:i:3:p:31-491:d:1212672
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