IDEAS home Printed from https://ideas.repec.org/a/gam/jjopen/v4y2021i1p5-81d520072.html
   My bibliography  Save this article

Antihypertensives’ Rock around the Clock

Author

Listed:
  • Ognjenka Rahić

    (Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Sarajevo, Zmaja od Bosne 8, 71000 Sarajevo, Bosnia and Herzegovina)

  • Amina Tucak

    (Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Sarajevo, Zmaja od Bosne 8, 71000 Sarajevo, Bosnia and Herzegovina)

  • Merima Sirbubalo

    (Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Sarajevo, Zmaja od Bosne 8, 71000 Sarajevo, Bosnia and Herzegovina)

  • Lamija Hindija

    (Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Sarajevo, Zmaja od Bosne 8, 71000 Sarajevo, Bosnia and Herzegovina)

  • Jasmina Hadžiabdić

    (Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Sarajevo, Zmaja od Bosne 8, 71000 Sarajevo, Bosnia and Herzegovina)

Abstract

Although homeostasis is a commonly accepted concept, there is incontrovertible evidence that biological processes and functions are variable and that variability occurs in cycles. In order to explain and understand dysregulation, which has not been embraced by homeostatic principles, the allostatic model has emerged as the first serious challenge to homeostasis, going beyond its homeostatic roots. Circadian rhythm is the predominant variation in the body, and it is a pattern according to which many physiological and pathological events occur. As there is strong experimental and clinical evidence that blood pressure fluctuations undergo circadian rhythm, there is equally strong evidence that targeted time therapy for hypertension provides a better outcome of the disease. The research has gone even further throughout the development and approval process for the use of pulsatile drug release systems, which can be considered as an option for an even more convenient dosage regimen of the medicines needed.

Suggested Citation

  • Ognjenka Rahić & Amina Tucak & Merima Sirbubalo & Lamija Hindija & Jasmina Hadžiabdić, 2021. "Antihypertensives’ Rock around the Clock," J, MDPI, vol. 4(1), pages 1-20, March.
    • Handle: RePEc:gam:jjopen:v:4:y:2021:i:1:p:5-81:d:520072
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/2571-8800/4/1/5/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/2571-8800/4/1/5/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Maria Casagrande & Francesca Favieri & Viviana Langher & Angela Guarino & Enrico Di Pace & Giuseppe Germanò & Giuseppe Forte, 2020. "The Night Side of Blood Pressure: Nocturnal Blood Pressure Dipping and Emotional (dys)Regulation," IJERPH, MDPI, vol. 17(23), pages 1-11, November.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Ilaria Corbo & Giuseppe Forte & Francesca Favieri & Maria Casagrande, 2023. "Poor Sleep Quality in Aging: The Association with Mental Health," IJERPH, MDPI, vol. 20(3), pages 1-12, January.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jjopen:v:4:y:2021:i:1:p:5-81:d:520072. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.