IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v7y2010i4p1448-1466d7700.html
   My bibliography  Save this article

Alcoholism and Alternative Splicing of Candidate Genes

Author

Listed:
  • Toshikazu Sasabe

    (Department of Life Sciences, Graduate School of Arts and Sciences, the University of Tokyo, 3-8-1, Komaba, Meguro-ku, Tokyo, 153-8902, Japan)

  • Shoichi Ishiura

    (Department of Life Sciences, Graduate School of Arts and Sciences, the University of Tokyo, 3-8-1, Komaba, Meguro-ku, Tokyo, 153-8902, Japan)

Abstract

Gene expression studies have shown that expression patterns of several genes have changed during the development of alcoholism. Gene expression is regulated not only at the level of transcription but also through alternative splicing of pre-mRNA. In this review, we discuss some of the evidence suggesting that alternative splicing of candidate genes such as DRD2 (encoding dopamine D2 receptor) may form the basis of the mechanisms underlying the pathophysiology of alcoholism. These reports suggest that aberrant expression of splice variants affects alcohol sensitivities, and alcohol consumption also regulates alternative splicing. Thus, investigations of alternative splicing are essential for understanding the molecular events underlying the development of alcoholism.

Suggested Citation

  • Toshikazu Sasabe & Shoichi Ishiura, 2010. "Alcoholism and Alternative Splicing of Candidate Genes," IJERPH, MDPI, vol. 7(4), pages 1-19, March.
    • Handle: RePEc:gam:jijerp:v:7:y:2010:i:4:p:1448-1466:d:7700
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/7/4/1448/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/7/4/1448/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. S. John Mihic & Qing Ye & Marilee J. Wick & Vladimir V. Koltchine & Matthew D. Krasowski & Suzanne E. Finn & Maria Paola Mascia & C. Fernando Valenzuela & Kirsten K. Hanson & Eric P. Greenblatt & R. A, 1997. "Sites of alcohol and volatile anaesthetic action on GABAA and glycine receptors," Nature, Nature, vol. 389(6649), pages 385-389, September.
    2. Alessandro Usiello & Ja-Hyun Baik & Françoise Rougé-Pont & Roberto Picetti & Andrée Dierich & Marianne LeMeur & Pier Vincenzo Piazza & Emiliana Borrelli, 2000. "Distinct functions of the two isoforms of dopamine D2 receptors," Nature, Nature, vol. 408(6809), pages 199-203, November.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Katarzyna Świtała & Aleksandra Bojarczuk & Jacek Hajto & Marcin Piechota & Maciej Buryta & Agata Leońska-Duniec, 2022. "Impact of the DRD2 Polymorphisms on the Effectiveness of the Training Program," IJERPH, MDPI, vol. 19(9), pages 1-14, April.
    2. Alessandro Bertolino & Paolo Taurisano & Nicola Marco Pisciotta & Giuseppe Blasi & Leonardo Fazio & Raffaella Romano & Barbara Gelao & Luciana Lo Bianco & Madia Lozupone & Annabella Di Giorgio & Grazi, 2010. "Genetically Determined Measures of Striatal D2 Signaling Predict Prefrontal Activity during Working Memory Performance," PLOS ONE, Public Library of Science, vol. 5(2), pages 1-10, February.
    3. Ya-Qiang Zhang & Wei-Peng Lin & Li-Ping Huang & Bing Zhao & Cheng-Cheng Zhang & Dong-Min Yin, 2021. "Dopamine D2 receptor regulates cortical synaptic pruning in rodents," Nature Communications, Nature, vol. 12(1), pages 1-17, December.
    4. Vernon A. Benignus & Philip J. Bushnell & William K. Boyes, 2005. "Toward Cost‐Benefit Analysis of Acute Behavioral Effects of Toluene in Humans," Risk Analysis, John Wiley & Sons, vol. 25(2), pages 447-456, April.
    5. Agnieszka Boroń & Małgorzata Śmiarowska & Anna Grzywacz & Krzysztof Chmielowiec & Jolanta Chmielowiec & Jolanta Masiak & Tomasz Pawłowski & Dariusz Larysz & Andrzej Ciechanowicz, 2022. "Association of Polymorphism within the Putative miRNA Target Site in the 3′UTR Region of the DRD2 Gene with Neuroticism in Patients with Substance Use Disorder," IJERPH, MDPI, vol. 19(16), pages 1-21, August.
    6. Arvind Kumar & Kayla Kindig & Shanlin Rao & Afroditi-Maria Zaki & Sandip Basak & Mark S. P. Sansom & Philip C. Biggin & Sudha Chakrapani, 2022. "Structural basis for cannabinoid-induced potentiation of alpha1-glycine receptors in lipid nanodiscs," Nature Communications, Nature, vol. 13(1), pages 1-14, December.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:7:y:2010:i:4:p:1448-1466:d:7700. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.