IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v7y2010i4p1366-1378d7668.html
   My bibliography  Save this article

Alcohol and HCV Chronic Infection Are Risk Cofactors of Type 2 Diabetes Mellitus for Hepatocellular Carcinoma in Italy

Author

Listed:
  • Massimiliano Balbi

    (Department of Medicine, Internal Medicine 3rd, Pordenone Hospital, Via Montereale 24, Pordenone 33170, Italy)

  • Valter Donadon

    (Department of Medicine, Internal Medicine 3rd, Pordenone Hospital, Via Montereale 24, Pordenone 33170, Italy)

  • Michela Ghersetti

    (Department of Medicine, Internal Medicine 3rd, Pordenone Hospital, Via Montereale 24, Pordenone 33170, Italy)

  • Silvia Grazioli

    (Department of Medicine, Internal Medicine 3rd, Pordenone Hospital, Via Montereale 24, Pordenone 33170, Italy)

  • Giovanni Della Valentina

    (Department of Medicine, Internal Medicine 3rd, Pordenone Hospital, Via Montereale 24, Pordenone 33170, Italy)

  • Rita Gardenal

    (Department of Medicine, Internal Medicine 3rd, Pordenone Hospital, Via Montereale 24, Pordenone 33170, Italy)

  • Maria Dal Mas

    (Department of Medicine, Internal Medicine 3rd, Pordenone Hospital, Via Montereale 24, Pordenone 33170, Italy)

  • Pietro Casarin

    (Department of Medicine, Internal Medicine 3rd, Pordenone Hospital, Via Montereale 24, Pordenone 33170, Italy)

  • Giorgio Zanette

    (Diabetes Clinic, Pordenone Hospital, Via Montereale 24, Pordenone 33170, Italy)

  • Cesare Miranda

    (Diabetes Clinic, Pordenone Hospital, Via Montereale 24, Pordenone 33170, Italy)

  • Paolo Cimarosti

    (Community Addictions Service, Pordenone Hospital, Via Montereale 24, Pordenone 33170, Italy)

Abstract

Type 2 diabetes mellitus (DM2) has been associated with hepatocellular carcinoma (HCC) development. To study this relationship, we enrolled 465 HCC patients compared with 618 Cirrhotic cases and 490 Controls. The prevalence of DM2 is significantly higher in HCC patients with an Odds Ratio of 3.12 versus Controls. In HCC cases with alcohol abuse, the frequency of DM2 is the highest. In our HCC patients, when HCV infection is associated with alcohol abuse, the liver cancer develops earlier. In addition, multivariate analysis shows that alcohol consumption is an independent risk factor for HCC more relevant than HCV infection.

Suggested Citation

  • Massimiliano Balbi & Valter Donadon & Michela Ghersetti & Silvia Grazioli & Giovanni Della Valentina & Rita Gardenal & Maria Dal Mas & Pietro Casarin & Giorgio Zanette & Cesare Miranda & Paolo Cimaros, 2010. "Alcohol and HCV Chronic Infection Are Risk Cofactors of Type 2 Diabetes Mellitus for Hepatocellular Carcinoma in Italy," IJERPH, MDPI, vol. 7(4), pages 1-13, March.
    • Handle: RePEc:gam:jijerp:v:7:y:2010:i:4:p:1366-1378:d:7668
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/7/4/1366/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/7/4/1366/
    Download Restriction: no
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Tao Hu & Qingyun Du & Fu Ren & Shi Liang & Denan Lin & Jiajia Li & Yan Chen, 2014. "Spatial Analysis of the Home Addresses of Hospital Patients with Hepatitis B Infection or Hepatoma in Shenzhen, China from 2010 to 2012," IJERPH, MDPI, vol. 11(3), pages 1-13, March.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:7:y:2010:i:4:p:1366-1378:d:7668. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.