IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v20y2023i6p4999-d1094971.html
   My bibliography  Save this article

Could Vaspin Be a Potential Diagnostic Marker in Endometrial Cancer?

Author

Listed:
  • Dominika Pietrzyk

    (Department of Reconstructive Surgery and Gynecological Oncology, Pomeranian Medical University in Szczecin, Al. Powstańców Wielkopolskich 72, 70-111 Szczecin, Poland)

  • Piotr Tkacz

    (Department of Reconstructive Surgery and Gynecological Oncology, Pomeranian Medical University in Szczecin, Al. Powstańców Wielkopolskich 72, 70-111 Szczecin, Poland)

  • Mateusz Kozłowski

    (Department of Reconstructive Surgery and Gynecological Oncology, Pomeranian Medical University in Szczecin, Al. Powstańców Wielkopolskich 72, 70-111 Szczecin, Poland)

  • Sebastian Kwiatkowski

    (Department of Obstetrics and Gynecology, Pomeranian Medical University in Szczecin, Al. Powstańców Wielkopolskich 72, 70-111 Szczecin, Poland)

  • Małgorzata Rychlicka

    (Department of Nursing, Pomeranian Medical University, 71-210 Szczecin, Poland)

  • Ewa Pius-Sadowska

    (Department of General Pathology, Pomeranian Medical University in Szczecin, Al. Powstańców Wielkopolskich 72, 70-111 Szczecin, Poland)

  • Bogusław Machaliński

    (Department of General Pathology, Pomeranian Medical University in Szczecin, Al. Powstańców Wielkopolskich 72, 70-111 Szczecin, Poland)

  • Aneta Cymbaluk-Płoska

    (Department of Reconstructive Surgery and Gynecological Oncology, Pomeranian Medical University in Szczecin, Al. Powstańców Wielkopolskich 72, 70-111 Szczecin, Poland)

Abstract

Obesity and being overweight are risk factors for many types of cancer, including endometrial cancer. Adipose tissue is thought to be an endocrine organ that produces various hormones, including one known as vaspin. Insulin resistance, metabolic syndrome and type 2 diabetes are all associated with higher vaspin levels. A total of 127 patients divided into study (endometrial cancer) and control groups (non-cancerous) participated in this research. Serum vaspin levels were measured for all patients. The analysis was performed while taking into account grading and staging. In order to assess the usefulness of the tested protein as a new diagnostic marker, we used the plotting of a curve (ROC) and the calculation of the AUC curve to characterize the sensitivity and specificity of the parameters tested. We concluded that there were significantly lower vaspin levels in patients with endometrial cancer compared to patients with benign endometrial lesions. Vaspin may be a useful diagnostic marker in separating benign lesions from endometrial cancer.

Suggested Citation

  • Dominika Pietrzyk & Piotr Tkacz & Mateusz Kozłowski & Sebastian Kwiatkowski & Małgorzata Rychlicka & Ewa Pius-Sadowska & Bogusław Machaliński & Aneta Cymbaluk-Płoska, 2023. "Could Vaspin Be a Potential Diagnostic Marker in Endometrial Cancer?," IJERPH, MDPI, vol. 20(6), pages 1-12, March.
    • Handle: RePEc:gam:jijerp:v:20:y:2023:i:6:p:4999-:d:1094971
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/20/6/4999/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/20/6/4999/
    Download Restriction: no
    ---><---

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:20:y:2023:i:6:p:4999-:d:1094971. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.