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Boldine Alters Serum Lipidomic Signatures after Acute Spinal Cord Transection in Male Mice

Author

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  • Zachary A. Graham

    (Research Service, Birmingham VA Health Care System, Birmingham, AL 35233, USA
    Healthspan, Resilience & Performance, Florida Institute for Human and Machine Cognition, Pensacola, FL 32502, USA
    Department of Cell, Developmental, and Integrative Biology, University of Alabama-Birmingham, Birmingham, AL 35294, USA)

  • Jacob A. Siedlik

    (Department of Exercise Science and Pre-Health Professions, Creighton University, Omaha, NE 68178, USA
    School of Medicine, Creighton University, Omaha, NE 68178, USA)

  • Carlos A. Toro

    (Spinal Cord Damage Research Center, Bronx, NY 10468, USA
    Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA)

  • Lauren Harlow

    (Spinal Cord Damage Research Center, Bronx, NY 10468, USA)

  • Christopher P. Cardozo

    (Spinal Cord Damage Research Center, Bronx, NY 10468, USA
    Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
    Medical Service, James J. Peters VA Medical Center, Bronx, NY 10468, USA)

Abstract

Traumatic spinal cord injury (SCI) results in wide-ranging cellular and systemic dysfunction in the acute and chronic time frames after the injury. Chronic SCI has well-described secondary medical consequences while acute SCI has unique metabolic challenges as a result of physical trauma, in-patient recovery and other post-operative outcomes. Here, we used high resolution mass spectrometry approaches to describe the circulating lipidomic and metabolomic signatures using blood serum from mice 7 d after a complete SCI. Additionally, we probed whether the aporphine alkaloid, boldine, was able to prevent SCI-induced changes observed using these ‘omics platforms’. We found that SCI resulted in large-scale changes to the circulating lipidome but minimal changes in the metabolome, with boldine able to reverse or attenuate SCI-induced changes in the abundance of 50 lipids. Multiomic integration using xMWAS demonstrated unique network structures and community memberships across the groups.

Suggested Citation

  • Zachary A. Graham & Jacob A. Siedlik & Carlos A. Toro & Lauren Harlow & Christopher P. Cardozo, 2023. "Boldine Alters Serum Lipidomic Signatures after Acute Spinal Cord Transection in Male Mice," IJERPH, MDPI, vol. 20(16), pages 1-14, August.
    • Handle: RePEc:gam:jijerp:v:20:y:2023:i:16:p:6591-:d:1219058
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    References listed on IDEAS

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    1. Veronica L. Li & Yang He & Kévin Contrepois & Hailan Liu & Joon T. Kim & Amanda L. Wiggenhorn & Julia T. Tanzo & Alan Sheng-Hwa Tung & Xuchao Lyu & Peter-James H. Zushin & Robert S. Jansen & Basil Mic, 2022. "An exercise-inducible metabolite that suppresses feeding and obesity," Nature, Nature, vol. 606(7915), pages 785-790, June.
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