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Optimization of Ultrasonic-Assisted Extraction of Chlorogenic Acid from Tobacco Waste

Author

Listed:
  • Guoming Zeng

    (Chongqing Engineering Laboratory of Nano/Micro Biological Medicine Detection Technology, School of Architecture and Engineering, Chongqing University of Science and Technology, Chongqing 401331, China
    These two authors contributed equally to this work.)

  • Yujie Ran

    (Chongqing Engineering Laboratory of Nano/Micro Biological Medicine Detection Technology, School of Architecture and Engineering, Chongqing University of Science and Technology, Chongqing 401331, China
    These two authors contributed equally to this work.)

  • Xin Huang

    (Chongqing Engineering Laboratory of Nano/Micro Biological Medicine Detection Technology, School of Architecture and Engineering, Chongqing University of Science and Technology, Chongqing 401331, China)

  • Yan Li

    (School of Pharmacy, Taizhou Polytechnic College, Taizhou 225300, China)

  • Maolan Zhang

    (Chongqing Engineering Laboratory of Nano/Micro Biological Medicine Detection Technology, School of Architecture and Engineering, Chongqing University of Science and Technology, Chongqing 401331, China)

  • Hui Ding

    (Chongqing Engineering Laboratory of Nano/Micro Biological Medicine Detection Technology, School of Architecture and Engineering, Chongqing University of Science and Technology, Chongqing 401331, China)

  • Yonggang Ma

    (School of Pharmacy, Taizhou Polytechnic College, Taizhou 225300, China)

  • Hongshuo Ma

    (Chongqing Engineering Laboratory of Nano/Micro Biological Medicine Detection Technology, School of Architecture and Engineering, Chongqing University of Science and Technology, Chongqing 401331, China)

  • Libo Jin

    (Biomedical Collaborative Innovation Center of Zhejiang Province, Institute of Life Sciences, Wenzhou University, Wenzhou 325035, China)

  • Da Sun

    (Biomedical Collaborative Innovation Center of Zhejiang Province, Institute of Life Sciences, Wenzhou University, Wenzhou 325035, China)

Abstract

Using tobacco waste as raw material, the ultrasonic-assisted extraction of chlorogenic acid was optimized by response surface methodology (RSM). After repeated freezing and thawing of tobacco waste twice, the effect of pH value, ethanol volume fraction, temperature and extraction time on the extraction rate of chlorogenic acid was investigated by a single factor experiment. On the basis of this, the factors affecting the yield of chlorogenic acid were further optimized by using RSM. The optimum extraction conditions for chlorogenic acid were set at pH = 4.1, ethanol volume fraction was 49.57% and extraction time was 2.06 h. Under the above conditions, the extraction rate of chlorogenic acid could reach 0.502%, which was higher than traditional extraction and unpretreated ultrasonic extraction. All these results can be used as a reference for the extraction of effective ingredients in tobacco waste.

Suggested Citation

  • Guoming Zeng & Yujie Ran & Xin Huang & Yan Li & Maolan Zhang & Hui Ding & Yonggang Ma & Hongshuo Ma & Libo Jin & Da Sun, 2022. "Optimization of Ultrasonic-Assisted Extraction of Chlorogenic Acid from Tobacco Waste," IJERPH, MDPI, vol. 19(3), pages 1-10, January.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:3:p:1555-:d:738466
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