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Cross-Sectional Association of Urinary Bisphenol A and Vaccine-Induced Immunity against Hepatitis B Virus: Data from the 2003–2014 National Health and Nutrition Examination Survey

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  • Jun Young Uhm

    (Department of Medicine, Graduate School, The Catholic University of Korea, Seoul 06591, Korea)

  • Hyoung-Ryoul Kim

    (Department of Medicine, Graduate School, The Catholic University of Korea, Seoul 06591, Korea
    Department of Occupational & Environmental Medicine, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea)

Abstract

Hepatitis B virus (HBV) infection poses a serious health burden; bisphenol A (BPA), a commonly used plasticizer for consumer products, is a potential immune disruptor. However, epidemiologic studies revealing the association between BPA exposure and immunity are limited. This study investigates the association between environmental BPA exposure and immune response following HBV vaccination in a nationally representative sample population. Using National Health and Nutrition Examination Survey data from six cycles, we analyzed the data of 6134 participants, classified as susceptible to HBV infection ( n = 3086) or as having vaccine-induced immunity ( n = 3048). Associations between BPA level and HBV susceptibility were assessed using multivariable logistic regression and expressed as odds ratios (ORs) of the pooled data and data for each cycle. There was a significant association in the pooled data after adjusting for potential confounders (adjusted OR (aOR): 1.14, 95% confidence interval (CI): 1.05–1.23). However, the associations between BPA concentration and HBV susceptibility were inconsistent across the survey cycles and tended to decrease in more recent cycles. Although this study preliminarily suggests that BPA attenuates the immune response to hepatitis B vaccination, further prospective studies are warranted to elucidate the discrepancies observed.

Suggested Citation

  • Jun Young Uhm & Hyoung-Ryoul Kim, 2022. "Cross-Sectional Association of Urinary Bisphenol A and Vaccine-Induced Immunity against Hepatitis B Virus: Data from the 2003–2014 National Health and Nutrition Examination Survey," IJERPH, MDPI, vol. 19(3), pages 1-13, January.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:3:p:1103-:d:728438
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    References listed on IDEAS

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    1. Vogel, S.A., 2009. "The politics of plastics: the making and unmaking of bisphenol a "safety"," American Journal of Public Health, American Public Health Association, vol. 99(S3), pages 559-566.
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