IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v19y2022i2p843-d723335.html
   My bibliography  Save this article

Partial Replacement of Dietary Fat with Krill Oil or Coconut Oil Alleviates Dyslipidemia by Partly Modulating Lipid Metabolism in Lipopolysaccharide-Injected Rats on a High-Fat Diet

Author

Listed:
  • Hee-Kyoung Son

    (Research Center for Industrialization of Natural Neutralization, Dankook University, Cheonan 31116, Korea
    These authors contributed equally to this work.)

  • Bok-Hee Kim

    (Department of Food and Nutrition, Chosun University, Gwangju 61452, Korea
    These authors contributed equally to this work.)

  • Jisu Lee

    (Research Center for Industrialization of Natural Neutralization, Dankook University, Cheonan 31116, Korea
    Department of Food Science and Nutrition, Dankook University, Cheonan 31116, Korea)

  • Seohyun Park

    (Research Center for Industrialization of Natural Neutralization, Dankook University, Cheonan 31116, Korea
    Department of Food Science and Nutrition, Dankook University, Cheonan 31116, Korea)

  • Chung-Bae Oh

    (Office of Technical Liaison, Industry Support Team, Gyeongnam Branch Institute, Korea Institute of Toxicology, Jinju 52834, Korea)

  • Sunyoon Jung

    (Research Center for Industrialization of Natural Neutralization, Dankook University, Cheonan 31116, Korea
    Department of Food Science and Nutrition, Dankook University, Cheonan 31116, Korea)

  • Jennifer K. Lee

    (Food Science and Human Nutrition Department, University of Florida, Gainesville, FL 32611, USA)

  • Jung-Heun Ha

    (Research Center for Industrialization of Natural Neutralization, Dankook University, Cheonan 31116, Korea
    Department of Food Science and Nutrition, Dankook University, Cheonan 31116, Korea)

Abstract

This study investigated the effects of partial replacement of dietary fat with krill oil (KO) or coconut oil (CO) on dyslipidemia and lipid metabolism in rats fed with a high-fat diet (HFD). Sprague Dawley rats were divided into three groups as follows: HFD, HFD + KO, and HFD + CO. The rats were fed each diet for 10 weeks and then intraperitoneally injected with phosphate-buffered saline (PBS) or lipopolysaccharide (LPS) (1 mg/kg). The KO- and CO-fed rats exhibited lower levels of serum lipids and aspartate aminotransferases than those of the HFD-fed rats. Rats fed with HFD + KO displayed significantly lower hepatic histological scores and hepatic triglyceride (TG) content than rats fed with HFD. The KO supplementation also downregulated the adipogenic gene expression in the liver. When treated with LPS, the HFD + KO and HFD + CO groups reduced the adipocyte size in the epididymal white adipose tissues (EAT) relative to the HFD group. These results suggest that KO and CO could improve lipid metabolism dysfunction.

Suggested Citation

  • Hee-Kyoung Son & Bok-Hee Kim & Jisu Lee & Seohyun Park & Chung-Bae Oh & Sunyoon Jung & Jennifer K. Lee & Jung-Heun Ha, 2022. "Partial Replacement of Dietary Fat with Krill Oil or Coconut Oil Alleviates Dyslipidemia by Partly Modulating Lipid Metabolism in Lipopolysaccharide-Injected Rats on a High-Fat Diet," IJERPH, MDPI, vol. 19(2), pages 1-30, January.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:2:p:843-:d:723335
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/19/2/843/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/19/2/843/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Hee-Kyoung Son & Huo Xiang & Seohyun Park & Jisu Lee & Jae-Joon Lee & Sunyoon Jung & Jung-Heun Ha, 2021. "Partial Replacement of Dietary Fat with Polyunsaturated Fatty Acids Attenuates the Lipopolysaccharide-Induced Hepatic Inflammation in Sprague-Dawley Rats Fed a High-Fat Diet," IJERPH, MDPI, vol. 18(20), pages 1-26, October.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.

      Corrections

      All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:19:y:2022:i:2:p:843-:d:723335. See general information about how to correct material in RePEc.

      If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

      If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

      If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

      For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

      Please note that corrections may take a couple of weeks to filter through the various RePEc services.

      IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.