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Association of Long Noncoding RNA HOTAIR Polymorphism and the Clinical Manifestations of Diabetic Retinopathy

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  • Chih-Chun Chuang

    (Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
    Department of Ophthalmology, Changhua Christian Hospital, Changhua 500, Taiwan
    Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung 402, Taiwan)

  • Kai Wang

    (Department of Ophthalmology, Cathay General Hospital, Taipei 106, Taiwan
    Departments of Ophthalmology, Sijhih Cathay General Hospital, New Taipei City 221, Taiwan
    School of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei City 242, Taiwan)

  • Yi-Sun Yang

    (School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
    Department of Internal Medicine, Division of Endocrinology and Metabolism, Chung Shan Medical University Hospital, Taichung 402, Taiwan)

  • Edy Kornelius

    (School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
    Department of Internal Medicine, Division of Endocrinology and Metabolism, Chung Shan Medical University Hospital, Taichung 402, Taiwan)

  • Chih-Hsin Tang

    (School of Medicine, China Medical University, Taichung 404, Taiwan
    Department of Medical Laboratory Science and Biotechnology, College of Medical and Health Science, Asia University, Taichung 413, Taiwan)

  • Chia-Yi Lee

    (Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
    Department of Ophthalmology, Nobel Eye Institute, Taipei 115, Taiwan)

  • Hsiang-Wen Chien

    (Department of Ophthalmology, Cathay General Hospital, Taipei 106, Taiwan
    Departments of Ophthalmology, Sijhih Cathay General Hospital, New Taipei City 221, Taiwan
    School of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei City 242, Taiwan
    School of Medicine, National Tsing Hua University, Hsinchu 300, Taiwan)

  • Shun-Fa Yang

    (Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
    Department of Medical Research, Chung Shan Medical University Hospital, Taichung 402, Taiwan)

Abstract

The aim of the current study is to evaluate the possible correlation between the single-nucleotide polymorphisms (SNP) of HOX transcript antisense intergenic RNA (HOTAIR) and the clinical characteristics of diabetic retinopathy (DR). Four loci of HOTAIR SNPs, including rs920778 (T/C), rs12427129 (C/T), rs4759314 (A/G), and rs1899663 (G/T), were genotyped via the TaqMan allelic discrimination for 276 DR individuals and 452 non-DR patients. The distribution frequency of HOTAIR SNP rs12427129 CT [adjusted odds ratio (AOR): 1.571, 95% CI: 1.025–2.408, p = 0.038], HOTAIR SNP rs12427129 CT+TT (AOR: 1.611, 95% CI: 1.061–2.446, p = 0.025), and HOTAIR SNP rs1899663 TT (AOR: 2.443, 95% CI: 1.066–5.595, p = 0.035) were significantly higher in the DR group. Moreover, the proliferative diabetic retinopathy (PDR) subgroup revealed a significantly higher distribution of HOTAIR SNP rs12427129 CT+TT (AOR: 2.016, 95% CI: 1.096–3.710, p = 0.024) and HOTAIR SNP rs1899663 TT (AOR: 4.693, 95% CI: 1.765–12.479, p = 0.002), and the distribution frequencies of HOTAIR SNP rs12427129 CT (AOR: 3.722, 95% CI: 1.555–8.909, p = 0.003), HOTAIR SNP rs12427129 CT+TT (AOR: 4.070, 95% CI: 1.725–9.600, p = 0.001), and HOTAIR SNP rs1899663 TT (AOR: 11.131, 95% CI: 1.521–81.490, p = 0.018) were significantly higher in the female PDR subgroup. Regarding the clinical characters, the DR patients with HOTAIR SNP rs1899663 GT+TT revealed a significantly shorter duration of diabetes compared to the DR patients with HOTAIR SNP rs1899663 GG (10.54 ± 8.19 versus 12.79 ± 7.73, p = 0.024). In conclusion, HOTAIR SNP rs12427129 and rs1899663 are strongly correlated to the presence of DR, especially for a female with PDR.

Suggested Citation

  • Chih-Chun Chuang & Kai Wang & Yi-Sun Yang & Edy Kornelius & Chih-Hsin Tang & Chia-Yi Lee & Hsiang-Wen Chien & Shun-Fa Yang, 2022. "Association of Long Noncoding RNA HOTAIR Polymorphism and the Clinical Manifestations of Diabetic Retinopathy," IJERPH, MDPI, vol. 19(21), pages 1-10, November.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:21:p:14592-:d:965199
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    Keywords

    lung cancer; GAS5; polymorphism; EGFR mutation;
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