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Genetic Evolution Analysis and Host Characteristics of Hantavirus in Yunnan Province, China

Author

Listed:
  • Na Wang

    (School of Public Health, Dali University, Dali 671000, China)

  • Jia-Xiang Yin

    (School of Public Health, Dali University, Dali 671000, China)

  • Yao Zhang

    (School of Public Health, Dali University, Dali 671000, China)

  • Li Wu

    (School of Public Health, Dali University, Dali 671000, China)

  • Wen-Hong Li

    (School of Public Health, Dali University, Dali 671000, China)

  • Yun-Yan Luo

    (School of Public Health, Dali University, Dali 671000, China)

  • Rui Li

    (School of Public Health, Dali University, Dali 671000, China)

  • Zi-Wei Li

    (School of Public Health, Dali University, Dali 671000, China)

  • Shu-Qing Liu

    (School of Public Health, Dali University, Dali 671000, China)

Abstract

For a long time, the epidemic situation of hemorrhagic fever with renal syndrome (HFRS) caused by hantavirus (HV) in Yunnan Province of China has been relatively severe. The molecular epidemiology and host characteristics of HV in Yunnan Province are still not completely clear, and the systematic and long-term investigation of the epidemic area is very limited. In this study, a total of 488 murine-shaped animals were captured in the three regions of Mile City, Mangshi City and Lianghe County in Yunnan Province, and then the type of HV was identified by multiplex real-time RT-PCR and sequenced. The results indicate that 2.46% of the murine-shaped animal specimens were infected with HV. A new subtype of Seoul virus (SEOV) was found in the rare rat species Rattus nitidus in Lianghe County, and the two strains of this new subtype were named YNLH-K40 and YNLH-K53. Through the phylogenetic analysis of this new subtype, it is shown that this new subtype is very similar to the type S5 of SEOV, which is previously described as the main cause for the high incidence of HFRS in Longquan City, Zhejiang Province, China. This new subtype is highly likely to cause human infection and disease. Therefore, in addition to further promoting the improvement of the HV gene database and strengthening the discovery and monitoring of the host animals in Yunnan Province, more attention should be paid to the pathogenic potential of the newly discovered HV type.

Suggested Citation

  • Na Wang & Jia-Xiang Yin & Yao Zhang & Li Wu & Wen-Hong Li & Yun-Yan Luo & Rui Li & Zi-Wei Li & Shu-Qing Liu, 2022. "Genetic Evolution Analysis and Host Characteristics of Hantavirus in Yunnan Province, China," IJERPH, MDPI, vol. 19(20), pages 1-11, October.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:20:p:13433-:d:945339
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    References listed on IDEAS

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    1. Chi-Jeng Hsieh & Chuan-Wang Li & Chun-An Cheng & Ding-Chung Wu & Wen-Chih Wu & Fu-Huang Lin & Yu-Ching Chou & Chia-Peng Yu, 2020. "Epidemiologic Characteristics of Domestic Patients with Hemorrhagic Fever with Renal Syndrome in Taiwan: A 19-Year Retrospective Study," IJERPH, MDPI, vol. 17(15), pages 1-13, July.
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