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Continuous Oral Administration of Sonicated P. gingivalis Delays Rat Skeletal Muscle Healing Post-Treadmill Training

Author

Listed:
  • Kairi Hayashi

    (Department of Masticatory Function and Health Science, Graduate School of Medical and Dental Science, Tokyo Medical and Dental University, Tokyo 113-8510, Japan
    Division of Sports Dentistry of Sports Science Organization, Tokyo Medical and Dental University, Tokyo 113-8510, Japan)

  • Yasuo Takeuchi

    (Department of Periodontology, Graduate School of Medical and Dental Science, Tokyo Medical and Dental University, Tokyo 113-8510, Japan)

  • Shintaro Shimizu

    (Department of Masticatory Function and Health Science, Graduate School of Medical and Dental Science, Tokyo Medical and Dental University, Tokyo 113-8510, Japan)

  • Gen Tanabe

    (Department of Oral Microbiology, Asahi University School of Dentistry, Gifu 501-0296, Japan)

  • Hiroshi Churei

    (Department of Masticatory Function and Health Science, Graduate School of Medical and Dental Science, Tokyo Medical and Dental University, Tokyo 113-8510, Japan
    Division of Sports Dentistry of Sports Science Organization, Tokyo Medical and Dental University, Tokyo 113-8510, Japan)

  • Hiroaki Kobayashi

    (Department of Periodontology, Graduate School of Medical and Dental Science, Tokyo Medical and Dental University, Tokyo 113-8510, Japan)

  • Toshiaki Ueno

    (Department of Sports Dentistry, Meikai University School of Dentistry, Saitama 350-0283, Japan)

Abstract

Background: A delay in muscle repair interferes with the effect of training or exercise; therefore, it is important to identify the factors that delay muscle repair. P. gingivalis , one of the most common periodontal disease pathogens, has the potential to inhibit muscle repair after training, as inferred from a previous study. To assess the expression of satellite cells in this in vivo study, we evaluated the relationship between P. gingivalis and muscle regeneration after training. Methods: A total of 20 male Wistar rats (eight weeks in age) were randomly divided into two groups: one orally administered sonicated P. gingivalis four times per week for six weeks (PG group) and one given no treatment (NT group). After four weeks of training using a treadmill, the gastrocnemius was evaluated using histology of the cross-sectional area (CSA) of myotubes and immunohistochemistry of the expression of skeletal muscle satellite cells. In addition, an endurance test was performed a day before euthanization. Results: The CSA and expression of Pax7+/MyoD− and Pax7+/MyoD+ cells were not significantly different between the groups. However, the expression of Pax7−/MyoD+ cells and running time until exhaustion were significantly lower in the PG group. Conclusions: Infection with P. gingivalis likely interferes with muscle repair after training.

Suggested Citation

  • Kairi Hayashi & Yasuo Takeuchi & Shintaro Shimizu & Gen Tanabe & Hiroshi Churei & Hiroaki Kobayashi & Toshiaki Ueno, 2022. "Continuous Oral Administration of Sonicated P. gingivalis Delays Rat Skeletal Muscle Healing Post-Treadmill Training," IJERPH, MDPI, vol. 19(20), pages 1-10, October.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:20:p:13046-:d:939026
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    Cited by:

    1. Tasuku Yoshimoto & Yoko Hasegawa & Mayuka Furihata & Akihiro Yoshihara & Masako Shiramizu & Ma. Therese Sta. Maria & Shoko Hori & Mayuko Morikawa & Pinta Marito & Noboru Kaneko & Kaname Nohno & Hirosh, 2022. "Effects of Interval Walking Training on Oral Health Status in Middle-Aged and Older Adults: A Case-Control Study," IJERPH, MDPI, vol. 19(21), pages 1-11, November.

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