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The Relationship between Late-Life Depression and Cognitive Function in Older Korean Adults: A Moderation Analysis of Physical Activity Combined with Lower-Body Muscle Strength

Author

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  • Jiyoung Kong

    (College of Sport Science, Sungkyunkwan University, Suwon 16419, Korea
    Jiyoung Kong and Minjung Kang equally contributed to the manuscript.)

  • Minjeong Kang

    (College of Sport Science, Sungkyunkwan University, Suwon 16419, Korea
    Jiyoung Kong and Minjung Kang equally contributed to the manuscript.)

  • Hyunsik Kang

    (College of Sport Science, Sungkyunkwan University, Suwon 16419, Korea)

Abstract

Background: This study examined the relationship of physical activity (PA) combined with lower-body muscle strength to late-life depression and cognitive impairment in 10,097 participants (6062 females) ≥ 65 years of age. Methods: Exposures were PA, sit-to-stand test (STST), and depressive symptoms. Outcome was cognitive performance. Results: Depressed individuals had an increased risk of mild cognitive impairment (MCI; odds ratio (OR), adjusted OR = 1.845 and 95% confidence interval (CI) = 1.580–2.154, p < 0.001) compared with non-depressed individuals. Individuals who had insufficient PA and a poor STST and either insufficient PA or a poor STST had an increased risk of MCI (adjusted OR = 1.329 and 95% CI = 1.209–1.46, p < 0.001 and adjusted OR = 2.822 and 95% CI = 2.488–3.200, p < 0001, respectively) compared with individuals who had sufficient PA and a good STST. A significant moderation effect of PA combined with lower-body muscle strength on the relationship between depression and cognitive function was observed (β = −1.3923; 95% CI = −2.1505 to −0.6341, p < 0.003). Conclusions: The negative effect of late-life depression on cognitive function was incremental in the order of sufficient PA and a good STST, insufficient PA or a poor STST, and insufficient PA and a poor STST.

Suggested Citation

  • Jiyoung Kong & Minjeong Kang & Hyunsik Kang, 2022. "The Relationship between Late-Life Depression and Cognitive Function in Older Korean Adults: A Moderation Analysis of Physical Activity Combined with Lower-Body Muscle Strength," IJERPH, MDPI, vol. 19(14), pages 1-11, July.
  • Handle: RePEc:gam:jijerp:v:19:y:2022:i:14:p:8769-:d:866109
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    References listed on IDEAS

    as
    1. Manqiong Yuan & Hanhan Fu & Ruoyun Liu & Ya Fang, 2020. "Effect of Frequency of Exercise on Cognitive Function in Older Adults: Serial Mediation of Depression and Quality of Sleep," IJERPH, MDPI, vol. 17(3), pages 1-10, January.
    2. Adilson Marques & Diego Gomez-Baya & Miguel Peralta & Diana Frasquilho & Teresa Santos & João Martins & Gerson Ferrari & Margarida Gaspar de Matos, 2020. "The Effect of Muscular Strength on Depression Symptoms in Adults: A Systematic Review and Meta-Analysis," IJERPH, MDPI, vol. 17(16), pages 1-13, August.
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