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The Effect of Chronic Immunosuppressive Regimens Treatment on Aortal Media Morphology and the Balance between Matrix Metalloproteinases (mmp-2 and mmp-9) and Their Inhibitors in the Abdominal Aorta of Rats

Author

Listed:
  • Anna Surówka

    (Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, 70-111 Szczecin, Poland)

  • Kamila Szumilas

    (Department of Physiology, Pomeranian Medical University, 70-111 Szczecin, Poland)

  • Aleksandra Wilk

    (Department of Histology and Embryology, Pomeranian Medical University, 70-111 Szczecin, Poland)

  • Kamila Misiakiewicz-Has

    (Department of Histology and Embryology, Pomeranian Medical University, 70-111 Szczecin, Poland)

  • Kazimierz Ciechanowski

    (Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, 70-111 Szczecin, Poland)

  • Karolina Kędzierska-Kapuza

    (Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, 70-111 Szczecin, Poland
    Clinical Department of Gastroenterological Surgery and Transplantation, Postgraduate Medical Education Centre in Warsaw, 02-507 Warsaw, Poland)

Abstract

Immunosuppressive drugs are widely and chronically used to avoid graft rejection in transplant recipients. However, they are also known to have organotoxic effects and can exert numerous side effects. The aim of this study was to assess whether the chronic treatment of rats with the most commonly used clinical immunosuppressive regimens in organ recipients had an effect on the morphology and function of the aorta. The rats were divided into five groups and each group was chronically treated with different sets of three immunosuppressive drugs (TRG, CRG, MRG, CMG, TMG) for 6 months. The changes were most profound in calcineurin inhibitor-based protocols. TMG protocol treatment was characterized by the most numerous alterations such as morphological changes, changes in the thickness of the tunic media, wider distances between elastic lamellae, an increase in the number of vSMCs and changes in collagen deposition. We concluded that the morphological changes were connected with MMP-2 and MMP-9/TIMP-2 and TIMP-1 imbalances, which was also determined and noticed.

Suggested Citation

  • Anna Surówka & Kamila Szumilas & Aleksandra Wilk & Kamila Misiakiewicz-Has & Kazimierz Ciechanowski & Karolina Kędzierska-Kapuza, 2022. "The Effect of Chronic Immunosuppressive Regimens Treatment on Aortal Media Morphology and the Balance between Matrix Metalloproteinases (mmp-2 and mmp-9) and Their Inhibitors in the Abdominal Aorta of," IJERPH, MDPI, vol. 19(11), pages 1-16, May.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:11:p:6399-:d:823184
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