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Hemodynamic Response to High- and Low-Load Resistance Exercise in Patients with Coronary Artery Disease: A Randomized, Crossover Clinical Trial

Author

Listed:
  • Tim Kambic

    (Department of Research and Education, General Hospital Murska Sobota, 9000 Murska Sobota, Slovenia)

  • Vedran Hadžić

    (Faculty of Sport, University of Ljubljana, 1000 Ljubljana, Slovenia)

  • Mitja Lainscak

    (Division of Cardiology, General Hospital Murska Sobota, 9000 Murska Sobota, Slovenia
    Faculty of Medicine, University of Ljubljana, 1000 Ljubljana, Slovenia
    Faculty of Natural Sciences and Mathematics, University of Maribor, 2000 Maribor, Slovenia)

Abstract

Low-load resistance exercise (LL-RE) is recommended as an adjunct therapy to aerobic exercise during cardiac rehabilitation in patients with coronary artery disease. The safety and hemodynamic response to high-load (HL) RE remain unknown. The aim of this study was to evaluate the hemodynamic response during both HL-RE and LL-RE prior to cardiac rehabilitation. Forty-three patients with coronary artery disease and/or percutaneous coronary intervention performed three sets of leg-press exercise using HL-RE (eight repetitions at the intensity of 80% of one repetition maximum (1-RM)) and LL-RE (16 repetitions at the intensity of 40% 1-RM) in a randomized crossover sequence. Heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), and rating of perceived exertion were measured at baseline, after each set of RE and post-exercise. No clinically relevant changes in HR and BP or in patient-reported symptoms were recorded during HL-RE or LL-RE. Compared with baseline, HR and SBP increased during LL-RE (from 66 bpm to 86 bpm, time effect: p < 0.001; from 129 mmHg to 146 mmHg, time effect: p < 0.001) and HL-RE (from 68 bpm to 86 bpm, time effect: p < 0.001; from 130 mmHg to 146 mmHg, time effect: p < 0.001). Compared with HL-RE, the increase in HR was greater after the final set of LL-RE (32% vs. 28%, p = 0.015), without significant differences in SBP and DBP between LL-RE and HL-RE. Rating of perceived exertion was higher after the 1st set of HL-RE compared with LL-RE (median (interquartile range): 6 (5–7) vs. 6 (5–6), p = 0.010). In patients with coronary artery disease, both HL-RE and LL-RE were safe and well-tolerated. Hemodynamic changes were similar and within the physiological response to RE.

Suggested Citation

  • Tim Kambic & Vedran Hadžić & Mitja Lainscak, 2021. "Hemodynamic Response to High- and Low-Load Resistance Exercise in Patients with Coronary Artery Disease: A Randomized, Crossover Clinical Trial," IJERPH, MDPI, vol. 18(8), pages 1-12, April.
  • Handle: RePEc:gam:jijerp:v:18:y:2021:i:8:p:3905-:d:532144
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