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Associations of Metabolic Genes ( GSTT1 , GSTP1 , GSTM1 ) and Blood Mercury Concentrations Differ in Jamaican Children with and without Autism Spectrum Disorder

Author

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  • Mohammad H. Rahbar

    (Department of Epidemiology, Human Genetics, and Environmental Sciences (EHGES), School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Biostatistics/Epidemiology/Research Design (BERD) Component, Center for Clinical and Translational Sciences (CCTS), The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Division of Clinical and Translational Sciences, Department of Internal Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA)

  • Maureen Samms-Vaughan

    (Department of Child & Adolescent Health, Mona Campus, The University of the West Indies (UWI), Kingston 7, Jamaica)

  • Sepideh Saroukhani

    (Department of Epidemiology, Human Genetics, and Environmental Sciences (EHGES), School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Biostatistics/Epidemiology/Research Design (BERD) Component, Center for Clinical and Translational Sciences (CCTS), The University of Texas Health Science Center at Houston, Houston, TX 77030, USA)

  • Jan Bressler

    (Department of Epidemiology, Human Genetics, and Environmental Sciences (EHGES), School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA)

  • Manouchehr Hessabi

    (Biostatistics/Epidemiology/Research Design (BERD) Component, Center for Clinical and Translational Sciences (CCTS), The University of Texas Health Science Center at Houston, Houston, TX 77030, USA)

  • Megan L. Grove

    (Department of Epidemiology, Human Genetics, and Environmental Sciences (EHGES), School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA)

  • Sydonnie Shakspeare-Pellington

    (Department of Child & Adolescent Health, Mona Campus, The University of the West Indies (UWI), Kingston 7, Jamaica)

  • Katherine A. Loveland

    (Louis A Faillace, MD, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77054, USA)

  • Compton Beecher

    (Department of Basic Medical Sciences, Mona Campus, The University of the West Indies, Kingston 7, Jamaica)

  • Wayne McLaughlin

    (Department of Basic Medical Sciences, Mona Campus, The University of the West Indies, Kingston 7, Jamaica
    Caribbean Genetics (CARIGEN), Mona Campus, The University of the West Indies, Kingston 7, Jamaica)

Abstract

We investigated interactive roles of three metabolic glutathione S-transferase (GST) genes ( GSTP1 , GSTT1 , and GSTM1 ) and autism spectrum disorder (ASD) status in relation to blood Hg concentrations (BHC) of Jamaican children. We used data from 266 children (2-8 years) with ASD and their 1:1 age- and sex-matched typically developing (TD) controls. After adjusting General Linear Models for child’s age, socioeconomic status, consumption of leafy vegetables, fried plantain, canned fish, and the interaction between GSTP1 and GSTT1 , we found significant interactions between GSTP1 and ASD status in relation to BHC either in a co-dominant or dominant genetic model for GSTP1 ( P < 0.001, P = 0.007, respectively). In the co-dominant model for the Ile105Val GSTP1 polymorphism, geometric mean (GM) BHC in ASD cases with genotype Ile/Ile were significantly higher than in cases with the Ile/Val genotype (0.73 vs. 0.48 µg/L, P = 0.01). In contrast, in TD controls with the Ile/Val genotype GM BHC were significantly higher than in those with the Ile/Ile genotype (0.72 vs. 0.49 µg/L, P = 0.03) or the Val/Val genotype (0.72 vs. 0.51 µg/L, P = 0.04). Although our findings are consistent with the role of GSTP1 in detoxification of Hg, replication in other populations is warranted.

Suggested Citation

  • Mohammad H. Rahbar & Maureen Samms-Vaughan & Sepideh Saroukhani & Jan Bressler & Manouchehr Hessabi & Megan L. Grove & Sydonnie Shakspeare-Pellington & Katherine A. Loveland & Compton Beecher & Wayne , 2021. "Associations of Metabolic Genes ( GSTT1 , GSTP1 , GSTM1 ) and Blood Mercury Concentrations Differ in Jamaican Children with and without Autism Spectrum Disorder," IJERPH, MDPI, vol. 18(4), pages 1-20, February.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:4:p:1377-:d:492153
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    References listed on IDEAS

    as
    1. Leandro V.B. Carvalho & Sandra S. Hacon & Claudia M. Vega & Jucilene A. Vieira & Ariane L. Larentis & Rita C. O. C. Mattos & Daniel Valente & Isabele C. Costa-Amaral & Dennys S. Mourão & Gabriela P. S, 2019. "Oxidative Stress Levels Induced by Mercury Exposure in Amazon Juvenile Populations in Brazil," IJERPH, MDPI, vol. 16(15), pages 1-15, July.
    2. Mohammad H. Rahbar & Maureen Samms-Vaughan & Meagan R. Pitcher & Jan Bressler & Manouchehr Hessabi & Katherine A. Loveland & MacKinsey A. Christian & Megan L. Grove & Sydonnie Shakespeare-Pellington &, 2016. "Role of Metabolic Genes in Blood Aluminum Concentrations of Jamaican Children with and without Autism Spectrum Disorder," IJERPH, MDPI, vol. 13(11), pages 1-19, November.
    3. Mohammad H. Rahbar & Maureen Samms-Vaughan & Jianzhong Ma & Jan Bressler & Katherine A. Loveland & Manouchehr Ardjomand-Hessabi & Aisha S. Dickerson & Megan L. Grove & Sydonnie Shakespeare-Pellington , 2014. "Role of Metabolic Genes in Blood Arsenic Concentrations of Jamaican Children with and without Autism Spectrum Disorder," IJERPH, MDPI, vol. 11(8), pages 1-22, August.
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    Cited by:

    1. Mohammad H. Rahbar & Shahnaz H. Ibrahim & Syed Iqbal Azam & Manouchehr Hessabi & Fatima Karim & Sori Kim & Jing Zhang & Nasreen Gulzar Ali & Katherine A. Loveland, 2021. "Concentrations of Lead, Mercury, Arsenic, Cadmium, Manganese, and Aluminum in the Blood of Pakistani Children with and without Autism Spectrum Disorder and Their Associated Factors," IJERPH, MDPI, vol. 18(16), pages 1-18, August.

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