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Exercise as a Peripheral Circadian Clock Resynchronizer in Vascular and Skeletal Muscle Aging

Author

Listed:
  • Bruna Spolador de Alencar Silva

    (Exercise and Immunometabolism Research Group, Universidade Estadual Paulista (UNESP), Presidente Prudente, São Paulo 19060-560, Brazil)

  • Juliana Souza Uzeloto

    (Exercise and Immunometabolism Research Group, Universidade Estadual Paulista (UNESP), Presidente Prudente, São Paulo 19060-560, Brazil)

  • Fábio Santos Lira

    (Exercise and Immunometabolism Research Group, Universidade Estadual Paulista (UNESP), Presidente Prudente, São Paulo 19060-560, Brazil)

  • Telmo Pereira

    (Clinical Physiology, Coimbra Health School, Polytechnic Institute of Coimbra, Rua 5 de Outubro—SM Bispo, Apartado 7006, 3046-854 Coimbra, Portugal
    Laboratory for Applied Health Research (LabinSaúde), Rua 5 de Outubro—SM Bispo, Apartado 7006, 3046-854 Coimbra, Portugal)

  • Manuel J. Coelho-E-Silva

    (Faculty of Sport Science and Physical Education, University of Coimbra, 3004-531 Coimbra, Portugal)

  • Armando Caseiro

    (Laboratory for Applied Health Research (LabinSaúde), Rua 5 de Outubro—SM Bispo, Apartado 7006, 3046-854 Coimbra, Portugal
    Unidade I&D Química-Física Molecular, Faculdade de Ciências e Tecnologia, Universidade de Coimbra, 3004-535 Coimbra, Portugal
    Biomedical Laboratory Sciences, Coimbra Health School, Polytechnic Institute of Coimbra, Rua 5 de Outubro—SM Bispo, Apartado 7006, 3046-854 Coimbra, Portugal)

Abstract

Aging is characterized by several progressive physiological changes, including changes in the circadian rhythm. Circadian rhythms influence behavior, physiology, and metabolic processes in order to maintain homeostasis; they also influence the function of endothelial cells, smooth muscle cells, and immune cells in the vessel wall. A clock misalignment could favor vascular damage and indirectly also affect skeletal muscle function. In this review, we focus on the dysregulation of circadian rhythm due to aging and its relationship with skeletal muscle changes and vascular health as possible risk factors for the development of sarcopenia, as well as the role of physical exercise as a potential modulator of these processes.

Suggested Citation

  • Bruna Spolador de Alencar Silva & Juliana Souza Uzeloto & Fábio Santos Lira & Telmo Pereira & Manuel J. Coelho-E-Silva & Armando Caseiro, 2021. "Exercise as a Peripheral Circadian Clock Resynchronizer in Vascular and Skeletal Muscle Aging," IJERPH, MDPI, vol. 18(24), pages 1-15, December.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:24:p:12949-:d:697751
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