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Pre-Exposure Prophylaxis (PrEP) Adherence Questionnaire: Psychometric Validation among Sexually Transmitted Infection Patients in China

Author

Listed:
  • Xiaoyue Yu

    (School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200003, China
    These authors contributed equally to this work.)

  • Chen Xu

    (School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200003, China
    These authors contributed equally to this work.)

  • Yang Ni

    (School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200003, China
    Shanghai Skin Disease Hospital, Shanghai 200040, China
    These authors contributed equally to this work.)

  • Ruijie Chang

    (School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200003, China)

  • Huwen Wang

    (School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200003, China)

  • Ruijie Gong

    (School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200003, China
    Shanghai Xuhui Center for Disease Control and Prevention, Shanghai 200030, China)

  • Ying Wang

    (School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200003, China)

  • Suping Wang

    (School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200003, China)

  • Yong Cai

    (School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200003, China)

Abstract

Background: Ensuring adherence guarantees the efficacy of pre-exposure prophylaxis (PrEP). Methods: We conducted a cross-sectional study among 816 sexually transmitted infection (STI) patients in Shanghai. The questionnaire included self-reported demographic characteristics, self-administered items on adherence to free oral PrEP, and PrEP uptake behavior measurement. We conducted item analysis, reliability analysis, validity analysis and receiver operating characteristic (ROC) curve analysis. Results: Not all items were considered acceptable in the item analysis. The questionnaire had a McDonald’s ω coefficient of 0.847. The scale-level content validity index (CVI) was 0.938 and the item-level CVI of each item ranged from 0.750 to 1. In exploratory factor analysis, we introduced a four-factor model accounting for 79.838% of the aggregate variance, which was validated in confirmatory factor analysis. Adding PrEP adherence questionnaire scores contributed to prediction of PrEP uptake behavior ( p < 0.001) in regression analysis. The maximum area under the ROC curve was 0.778 (95% IC: 0.739–0.817). Conclusion: The PrEP adherence questionnaire presented psychometric validation among STI patients.

Suggested Citation

  • Xiaoyue Yu & Chen Xu & Yang Ni & Ruijie Chang & Huwen Wang & Ruijie Gong & Ying Wang & Suping Wang & Yong Cai, 2021. "Pre-Exposure Prophylaxis (PrEP) Adherence Questionnaire: Psychometric Validation among Sexually Transmitted Infection Patients in China," IJERPH, MDPI, vol. 18(20), pages 1-12, October.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:20:p:10980-:d:659785
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